毒理学数据质量评价现状与展望  

Status quo and prospects of toxicological data quality evaluation

作　　者：凌敏[1] 卞倩[1] LING Min;BIAN Qian(Institute of Toxicology and Risk Assessment,Jiangsu Provincial Center for Disease Control and Prevention,Nanjing 210009,China)

机构地区：[1]江苏省疾病预防控制中心毒理与风险评估研究所,江苏南京210009

出　　处：《中国药理学与毒理学杂志》2024年第10期787-795,共9页Chinese Journal of Pharmacology and Toxicology

摘　　要：毒理学数据的质量对于毒性评价和风险预测的科学性至关重要。整合多种证据流和提高毒理学数据的质量对于更有效、更准确地开展健康风险评估必不可少。目前,国际上常用的毒理学数据质量评价体系包括Klimisch评级系统和ToxRTool评价工具及近年来发展起来的SciRAP评价工具和综合风险信息系统工具。我国针对食品安全风险评估中的毒理学数据开发了TRAM可靠性评价工具。上述评价工具具有不同的应用背景和评价标准的适用性,各有优点和不足。The quality of toxicological data is critical to toxicity assessment and risk prediction.Integrating multiple streams of evidence and enhancing the quality of toxicological data are indispensable for more efficient and precise health risk assessment.There are several commonly used toxicology data quality evaluation systems abroad,which include Klimisch rating system,ToxRTool evaluation tool,the SciRAP evaluation tool and the integrated risk information system tool.The TRAM reliability evaluation tool is developed in China for toxicology data in food safety risk assessment.These evaluation tools have different backgrounds and applicability of evaluation standards.Each evaluation system also has its advantages and disadvantages.

关 键 词：毒理学数据质量 替代方法 数据质量评价体系 风险评估 

分 类 号：R99[医药卫生—毒理学]