卵泡期长效长方案助孕患者不同体质量指数对助孕结局的影响  

The impact of different body mass indexes on assisted pregnancy outcomes of the assisted pregnancy patients by the follicular phase long-acting long protocol

作　　者：黄玲玲 夏雷震 许定飞[1] 黄嘉膂 黎梦溪[1] 左慧君 范露 田莉峰[1] HUANG Ling-ling;XIA Lei-szhen;XU Ding-fei;HUANG Ji-lyu;LI Meng-xi;ZU Hui-jun;FAN la;TIAN Li-feng(Jengxi Maeral and Child Health Hopiral,Maternal and Child Healh Hopind of Nanchang Medioal College,Nanchang,jiangri 303000,Chine)

机构地区：[1]江西省妇幼保健院南昌医学院附属妇幼保健院,江西南昌330000

出　　处：《中国妇幼保健》2024年第19期3750-3755,共6页Maternal and Child Health Care of China

基　　金：江西省重点研发计划项目(20203BBGL7359)。

摘　　要：目的 探讨辅助生殖技术(ART)中卵泡期长效长方案助孕不同体质量指数(BMI)患者的助孕结局。方法 回顾性分析2017年1月—2021年12月在江西省妇幼保健院行卵泡期长效长方案助孕患者的临床资料,年龄<38岁,排除常见的与自然流产相关疾病。按照WHO推荐的亚洲BMI分类标准,将患者分为低BMI组(BMI<18.5 kg/m^(2))、正常BMI组(BMI 18.5~22.9 kg/m^(2))、超重组(BMI 23.0~24.9 kg/m^(2))及肥胖组(BMI≥25 kg/m^(2)),比较不同BMI组患者的基本情况,ART助孕后妊娠和产科结局。结果 不同BMI组患者早期流产率、妊娠期糖尿病、妊娠期高血压疾病、前置胎盘、出生体质量及出生缺陷发生率比较,差异均有统计学意义(均P<0.05),但晚期流产率、多胎率比较,差异均无统计学意义(均P>0.05)。多因素logistic回归分析发现,肥胖组的临床妊娠率是正常BMI组的1.22倍,流产率是正常BMI组的1.52倍。与正常BMI组相比,低BMI组妊娠期糖尿病发生率低,超重和肥胖组妊娠期糖尿病发生率是正常BMI组的1.61倍和1.57倍,妊娠期高血压疾病是正常BMI组的1.51倍和1.92倍。超重组出生缺陷发生率是正常BMI组的2.13倍,差异均有统计学意义(均P<0.05),各组之间每移植周期活产率比较,差异无统计学意义(P>0.05)。结论 ART助孕中,BMI可在一定程度上影响卵泡期长效长方案助孕患者妊娠和产科结局,BMI较高组结局较差,临床应结合患者实际情况采取对应的干预措施。Objective To explore the pregnancy outcomes of different Body mass index(BMI)in the follicular phase long-acting long protocol assisted fertilization patients using assisted reproductive technology.Methods A retrospective analysis was conducted on patients aged less than 38 years old who underwent the follicular phase long-acting long protocol assisted pregnancy at Jiangxi Maternal and Child Health Hospital from January 2017 to December 2021,excluding common diseases related to spontaneous abortion.According to the Asian Body Mass Index(BMI)grading standards recommended by WHO,patients were divided into low BMI group(BMI<18.5 kg/m^(2)),normal BMI group(BMI 18.5-22.9 kg/m^(2)),overweight group(BMI 23.0-24.9 kg/m^(2)),and obese group(BMI≥25 kg/m^(2)).The basic situ⁃ation,pregnancy and obstetric outcomes of patients in different BMI groups were compared.Results There were significant differences in early abortion rate,gestational diabetes,gestational hypertension,placenta previa,birth weight and birth defects among different BMI groups(P<0.05),but there were no significant differences in late abortion rate and multiple birth rate(P>0.05).Multivariate logistic regression analysis found that the clinical pregnancy rate in the obese group was 1.22 times higher than that in the normal BMI group,and the miscar⁃riage rate was 1.52 times higher than that in the normal BMI group.Compared with the normal BMI group,the incidence of gestational dia⁃betes in the low BMI group was lower,the incidence of gestational diabetes in the overweight and obesity group was 1.61 times and 1.57 times of that in the normal BMI group,and the incidence of hypertension in pregnancy was 1.51 times and 1.92 times of that in the normal BMI group.The incidence of birth defects in overweighgroup was 2.13 times higher than that of the normal BMI group,with statistical differ⁃ences(P<0.05).There was no statistically significant difference in live birth rates between the groups during each transplantation cycle(P>0.05).Conclusion In ART cycle

关 键 词：卵泡期长效长方案 体质量指数 助孕结局 

分 类 号：R714[医药卫生—妇产科学]