短串联重复序列基因分型在部分性葡萄胎诊断中的应用价值  

Application value of short tandem repeat genotyping in diagnosis of partial hydatidiform mole

作　　者：陈豪 王文慧[1] 张焕焕 过华蕾 CHEN Hao;WANG Wen-hui;ZHANG Huan-huan;GUO Hua-lei(Department of Pathology,Hangzhou Obstetrics and Gynecology Hospital,Hangzhou,Zhejiang 310016,China;Graduate School of Zhejiang Chinese Medical University,Hangzhou,Zhejiang 310053,China)

机构地区：[1]杭州市妇产科医院病理科,浙江杭州310016 [2]浙江中医药大学研究生院,浙江杭州310053 [3]杭州市妇产科医院生殖科

出　　处：《中国妇幼保健》2024年第19期3821-3824,共4页Maternal and Child Health Care of China

基　　金：浙江省卫生健康科技计划青年创新人才项目(2022KY1018)。

摘　　要：目的探讨短串联重复序列(STR)基因分型在部分性葡萄胎诊断中的临床应用价值。方法收集2020年1月—2022年10月在杭州市妇产科医院诊断为部分性葡萄胎和部分性葡萄胎不能除外的22例患者,进行P57免疫组化染色,并应用STR基因分型技术进行分子分型。结果通过STR基因分型,22例患者中单纯通过组织形态学和P57染色阳性诊断为部分性葡萄胎的符合率为68.18%(15/22)。结论STR基因分型对部分性葡萄胎是一种极为有效的精准诊断手段。Objective To explore the clinical application value of short tandem repeat(STR)genotyping in diagnosis of partial hyda⁃tidiform mole.Methods From January 2020 to October 2022,22 cases diagnosed as partial hydatidiform mole and"partial hydatidiform mole not exclude"in Hangzhou Obstetrics and Gynecology Hospital were collected,P57 immunohistochemical staining was conducted,and STR genotyping was performed for molecular typing.Results According to the results of STR genotyping,the coincidence rate of 22 cases diagnosed as partial hydatidiform mole by histomorphology and P57 staining was 68.18%.Conclusion STR genotyping is an effective meth⁃od for accurate diagnosis of partial hydatidiform mole.

关 键 词：短串联重复序列基因分型 部分性葡萄胎 P57染色 精准诊断 

分 类 号：R714.2[医药卫生—妇产科学]