甘桔冰梅片治疗急性咽炎的Meta分析和成本-效果分析  

Meta-analysis and Cost-effectiveness Analysis of Ganjiebingmei Tablet in the Treatment of Acute Pharyngitis

作　　者：王欣 徐蔓玲 陈小宁[2] 柴峰[3] 邓定建 王嘉玺[5] WANG Xin;XU Man-Ling;CHEN Xiao-Ning;CHAI Feng;DENG Ding-Jian;WANG Jia-Xi(Beijing Ainusen Pharmaceutical Technology Co.,LTD.,Beijing 100026,China;Department of Otolaryngology,Jiangsu Provincial Hospital of Traditional Chinese Medicine,Nanjing 210029,China;Department of Otolaryngology,Henan Provincial Hospital of Traditional Chinese Medicine,Zhengzhou 450053,China;Chongqing Rongchang District Hospital of Traditional Chinese Medicine,Chongqing 402460,China;Department of Otolaryngology,Oriental Hospital of Beijing University of Chinese Medicine,Beijing 100078,China)

机构地区：[1]北京艾诺森医药科技有限公司,北京100026 [2]江苏省中医院耳鼻喉科,南京210029 [3]河南省中医院耳鼻喉科,郑州450053 [4]重庆市荣昌区中医院,重庆402460 [5]北京中医药大学东方医院耳鼻喉科,北京100078

出　　处：《中国药物经济学》2024年第9期5-11,21,共8页China Journal of Pharmaceutical Economics

摘　　要：目的 比较甘桔冰梅片和清咽滴丸/甘桔冰梅片+基础药和清咽滴丸+基础药治疗急性咽炎的临床疗效和经济性。方法 对甘桔冰梅片和清咽滴丸/甘桔冰梅片+基础药和清咽滴丸+基础药治疗急性咽炎进行Meta分析。建立决策树模型,从医疗系统角度进行成本-效果分析。效果参数为临床有效率,来源于临床文献Meta分析,成本参数为药品治疗成本,计算增量成本-效果比(ICER),并通过单因素敏感性分析检验基础分析结果的稳定性。结果 Meta分析结果显示,甘桔冰梅片治疗急性咽炎的临床有效率高于清咽滴丸,差异有统计学意义[OR=0.06,95%CI(0.03,0.16),P<0.000 01];甘桔冰梅片+基础药治疗急性咽炎的临床有效率高于清咽滴丸+基础药,差异有统计学意义[OR=0.92,95%CI(0.35,2.42),P<0.000 01]。成本-效果分析显示,疗程为1周时,甘桔冰梅片较清咽滴丸治疗急性咽炎的临床有效率每增加1%,成本降低43.55元;疗程为1周时,甘桔冰梅片+基础药较清咽滴丸+基础药治疗急性咽炎的临床有效率每增加1%,成本降低51.47元。结论 与清咽滴丸比较,采用甘桔冰梅片治疗急性咽炎成本更低,临床效果更好,为具有经济学优势的方案。Objective To compare the clinical efficacy and economy of Ganjiebingmei tablets and Qingyan Dropping pills/Ganjiebingmei tablets plus basic drugs and Qingyan dropping pills plus basic drugs in the treatment of acute pharyngitis.Methods A meta-analysis was performed on the treatment of acute pharyngitis with Ganjiebingmei tablets and Qingyan dropping pills/Ganjiebingmei tablets plus basic drugs and Qingyan dropping pills plus basic drugs.A decision tree model was established,and cost-effectiveness analysis was carried out from the perspective of medical system.The effect parameter was clinical effective rate,which was derived from meta-analysis of clinical literature,and the cost parameter was drug treatment cost.The incremental cost-effectiveness ratio(ICER)was calculated,and the stability of the basic analysis results was tested by single factor sensitivity analysis.Results The results of meta-analysis showed that the clinical effective rate of Ganjiebingmei tablet in the treatment of acute pharyngitis was superior to that of Qingyan dropping pill,and the difference was statistically significant[OR=0.06,95%CI(0.03,0.16),P<0.00001].In the treatment of acute pharyngitis,the clinical effective rate of Ganjiebingmei tablet plus basic drug was superior to that of Qingyan dropping pill plus basic drug,and the difference was statistically significant[OR=0.92,95%CI(0.35,2.42),P<0.00001].Cost-effectiveness analysis showed that when the treatment course was 1 week,the clinical effective rate of Ganjiebingmei tablet was 1% higher than that of Qingyan dropping pill in the treatment of acute pharyngitis, and the cost was43.55 yuan lower;when the treatment course was 1 week, the clinical effective rate of Ganjiebingmei tablet plus basic medicine was1% higher than that of Qingyan dropping pill plus basic medicine in the treatment of acute pharyngitis, the cost was 51.47 yuanlower. Conclusion This study shows that in the treatment of patients with acute pharyngitis, Ganjiebingmei tablet has lower costand better clinical effect

关 键 词：甘桔冰梅片 急性咽炎 META分析 成本-效果分析 

分 类 号：R766.14[医药卫生—耳鼻咽喉科] R956[医药卫生—临床医学]