小儿传染性单核细胞增多症引起肝功能异常的高危因素  

High Risk Factors for Liver Function Caused by Pediatric Infectious Mononucleosis

作　　者：陈永洁 曾龙平 王连珍 CHEN Yong-Jie;ZENG Long-Ping;WANG Lian-Zhen(Department of Pediatrics,Ji'an Maternal and Child Health Hospital,Ji'an 343000,China)

机构地区：[1]吉安市妇幼保健院儿科,江西吉安343000

出　　处：《中国药物经济学》2024年第9期54-56,共3页China Journal of Pharmaceutical Economics

基　　金：吉安市指导性科技计划项目(20233-043554)。

摘　　要：目的 探讨小儿传染性单核细胞增多症(IM)引起肝功能异常的高危因素。方法 选取2018年1月至2022年12月吉安市妇幼保健院收治的100例IM患儿作为研究对象,根据患儿入院后天冬氨酸转氨酶检测结果将其分为肝功能正常组(n=61)与肝功能异常组(n=39)。统计肝功能正常组与肝功能异常组患儿年龄、性别、发热、白细胞计数、降钙素原(PCT)、C反应蛋白(CRP)、肌酸激酶同工酶(CK-MB)、淋巴细胞百分比、异型淋巴细胞百分比,采用多因素Logistic回归分析影响IM患儿肝功能异常的高危因素。结果 两组性别、发热患者比例、白细胞计数、PCT、CRP、CK-MB比较差异无统计学意义(P>0.05);肝功能异常组年龄大于肝功能正常组,淋巴细胞百分比、异型淋巴细胞百分比高于肝功能正常组,差异有统计学意义(P<0.05);Logistic回归分析显示,年龄大、淋巴细胞百分比高、异型淋巴细胞百分比高是IM患儿肝功能异常的独立危险因素(P<0.05)。结论 年龄大、淋巴细胞百分比高、异型淋巴细胞百分比高是IM患儿肝功能异常的独立危险因素,对此临床需予以高度重视。Objective To explore the high risk factors of liver function caused by pediatric infectious mononucleosis(IM).Methods 100 cases of IM children admitted to Ji'an Maternal and Child Health Hospital from January 2018 to December 2022 were selected as the study objects.According to the test results of partic aminotransferase after admission,the children were divided into normal liver function group(n=61)and abnormal liver function group(n=39).The age,sex,fever,white blood cell count,procalcitonin(PCT),C-reactive protein(CRP),creatine kinase isoenzyme(CK-MB),lymphocyte percentage and allotype lymphocyte percentage of the children with normal liver function and abnormal liver function were counted.Multiple Logistic regression was used to analyze the risk factors affecting abnormal liver function of the children with IM.Results There were no significant differences in gender,proportion of fever patients,white blood cell count,PCT,CRP and CK-MB between the two groups(P>0.05).The age of abnormal liver function group was higher than that of normal liver function group,and the percentage of lymphocyte and abnormal lymphocyte was higher than that of normal liver function group,the difference was statistically significant(P<0.05).Logistic regression analysis showed that old age,high percentage of lymphocytes and high percentage of heterogeneous lymphocytes were independent risk factors for abnormal liver function in children with IM(P<0.05).Conclusion Old age,high percentage of lymphocytes and high percentage of heterogeneous lymphocytes are independent risk factors for abnormal liver function in children with IM,which should be paid great attention to clinically.

关 键 词：传染性单核细胞增多症 肝功能异常 高危因素 淋巴细胞百分比 异型淋巴细胞百分比 

分 类 号：R725.5[医药卫生—儿科]