人血白蛋白辅助治疗对重度病理性黄疸新生儿免疫功能的影响  

Effect of Human Blood Albumin Adjuvant Therapy on Immune Function of Neonates with Severe Pathological Jaundice

作　　者：闵凡红 张洁 MIN Fan-Hong;ZHANG Jie(Neonatal Intensive Care Unit,Linyi Central Hospital,Linyi 276000,China)

机构地区：[1]临沂市中心医院新生儿重症监护室,山东临沂276000

出　　处：《中国药物经济学》2024年第9期73-75,共3页China Journal of Pharmaceutical Economics

摘　　要：目的 探讨人血白蛋白辅助治疗对重度病理性黄疸新生儿免疫功能的影响。方法 选取2022年1月至2023年6月临沂市中心医院收治的62例重度病理性黄疸新生儿为研究对象,根据治疗方式不同分为对照组与观察组,各31例。对照组予以蓝光照射治疗,观察组在对照组基础上采用人血白蛋白辅助治疗。比较两组患儿临床疗效、免疫功能指标及血清胆红素水平。结果 观察组治疗有效率高于对照组(P<0.05);治疗前,两组免疫功能指标比较差异无统计学意义(P>0.05);治疗后,观察组CD4^(+)、CD4^(+)/CD8^(+)高于对照组,CD8^(+)低于对照组,差异有统计学意义(P<0.05);治疗前,两组血清胆红素水平比较差异无统计学意义(P>0.05);治疗3d、6d后,观察组血清胆红素水平低于对照组(P<0.05)。结论 采用人血白蛋白辅助治疗重度病理性黄疸新生儿临床疗效显著,可有效提高患儿免疫功能,降低血清胆红素水平。Objective To explore the effect of human blood albumin adjuvant therapy on the immune function of neonates with severe pathological jaundice.Methods Sixty-two neonates with severe pathological jaundice treated in Linyi Central Hospital from January 2022 to June 2023 were selected as the study objects,and were divided into control group and observation group according to different treatment methods,with 31 cases in each group.The control group was treated with blue light irradiation,and the observation group was treated with human blood albumin adjuvant therapy based on the control group.The clinical efficacy,immune function indexes and serum bilirubin levels were compared between the two groups.Results The effective rate of the observation group was higher than that of the control group(P<0.05).Before treatment,there was no significant difference in immune function indexes between the two groups(P>0.05).After treatment,CD4^(+)and CD4^(+)/CD8^(+)in observation group were higher than those in control group,and CD8^(+)was lower than those in control group,the difference was statistically significant(P<0.05).Before treatment,there was no significant difference in serum bilirubin levels between the two groups(P>0.05).After 3 and 6 days of treatment,the serum bilirubin level in the observation group was lower than that in the control group(P<0.05).Conclusion The therapeutic effect of human blood albumin in the treatment of severe pathological jaundice is remarkable,which can effectively improve the immune function and reduce the level of serum bilirubin.

关 键 词：人血白蛋白 辅助治疗 重度病理性黄疸 新生儿 免疫功能 

分 类 号：R722.17[医药卫生—儿科] R985[医药卫生—临床医学]