中药圣愈汤治疗早发性卵巢功能不全的临床观察  

Clincal effects of Shengyu Decoction in treatment of premature ovarian insufficiency

作　　者：张保华 聂启勤 周小莉 胡明珠 张俊伟 雷撼 ZHANG Bao-hua;NIE Qi-qin;ZHOU Xiao-li;HU Ming-zhu;ZHANG Jun-wei;LEI Han(Department of Obstetrics and Gynecology,Pulan Branch of Renji Hospital,Shanghai Jiaotong University School of Medicine,Shanghai 200125,China;Department of Respiratory Medicine,Renji Hospital Affiliated to Shanghai Jiao Tong University School of Medicine,Shanghai 200125,China)

机构地区：[1]上海交通大学医学院附属仁济医院浦南分院妇产科,上海200125 [2]上海交通大学医学院附属仁济医院浦南分院呼吸科,上海200125

出　　处：《医药论坛杂志》2024年第17期1885-1889,共5页Journal of Medical Forum

基　　金：2021年上海市综合医院中西结合专项基金(ZHYY-ZXYJHZX-202108)。

摘　　要：目的 探讨中药圣愈汤治疗早发性卵巢功能不全(premature ovarian insufficiency, POI)患者的临床疗效。方法 选取2023年7月1日至2024年4月30日上海交通大学医学院附属仁济医院浦南分院妇科门诊收治的40例早发性卵巢功能不全患者,采用随机法将所有患者分为对照组、研究组,每组各20例。对照组用雌孕激素序贯疗法治疗,研究组用圣愈汤治疗,比较两组临床疗效、中医症状积分及性激素水平。结果 研究组治疗总有效率为95.0%,高于对照组的75.0%,差异有统计学意义(P<0.05)。治疗前,两组中医症状各项积分比较,差异无统计学意义(P>0.05)。治疗后,研究组各项中医证状积分低于对照组,差异有统计学意义(P<0.05)。治疗前,两组血清卵泡生成激素(follicle-stimulating hormone, FSH)、雌二醇(estradiol, E_(2))、促黄体生成激素(luteinizing hormone, LH)及抗缪勒氏管激素(anti-mullerian hormone, AMH)水平比较,差异无统计学意义(P>0.05)。两组治疗后,FSH和LH水平下降,E_(2)和AMH水平有上升,有统计学意义(P<0.05);治疗后研究组FSH、LH、AMH、E_(2)水平与对照组无明显差异,差异无统计学意义(P>0.05)。结论 圣愈汤应用于治疗早发性卵巢功能不全(POI)治疗效果明显,有利于改善患者临床症状及调节性激素水平。值得在临床上应用。Objective To observe the clincal effects of Shengyu Decoction in the treatment of premature ovarian insufficiency,(POI).Methods A total of 50 patients with premature ovarian insufficiency who were admitted to the gynecology outpatient department of Ruijin Hospital Affiliated to Shanghai Jiaotong University School of Medicine were selected from July 1st,2023 to April 30th,2024.All patients were randomly divided into a study group and a control group with 25 patients in each group.For the control group,estrogen and progesterone sequential therapy was used as the treatment method;the study group received Shengyu Decoction treatment.During the treatment process,strictly follow medical ethics and norms,and make a comprehensive evaluation of the efficacy of the two treatment methods.The clinical efficacy,traditional Chinese medicine(TCM)symptom score,and serum hormone levels of the two groups were carefully compared after treatment.Results Statistical analysis showed that the study group had a total effective rate of treatment as high as 92%,There is a significant difference compared to the control group at 76%(P<0.05).Before treatment,there was no significant difference in the TCM symptom scores between the two groups,which was not statistically significant(P>0.05).After treatment,the levels of follicle-stimulating hormone(FSH)and luteinizing hormone(LH)in both groups decreased,while the levels of estradiol(E_(2))and anti-mullerian hormone(AMH)increased,and these changes were statistically significant(P<0.05).Further comparison of serum hormone levels before and after treatment between the two groups showed that there was no significant difference in serum follicle-stimulating hormone(FSH),estradiol(E,),luteinizing hormone(LH),and anti-Mullerian hormone(AMH)levels between the two groups before treatment,which was not statistically significant(P>0.05).After treatment,both groups showed a decrease in FSH and LH levels and an increase in E,and AMH levels.These changes were statistically significant(P<0.05).However,there

关 键 词：气血理论 圣愈汤 早发性卵巢功能不全 性激素水平 

分 类 号：R271.9[医药卫生—中西医结合]