柳州市大气污染物一氧化碳对缺血性心脏病发病风险的前瞻性队列研究  

Risk of ischemic heart disease caused by atmosphere carbon monoxide in Liuzhou City:a prospective cohort study

作　　者：钟志诚 周丽芳 裴培 孙点剑一 苏莉[1] 蓝剑[6] ZHONG Zhi-cheng;ZHOU Li-fang;PEI Pei;SUN Dian-jian-yi;SU Li;LAN Jian(School of Public Health,Guangxi Medical University,Nanning,Guangxi 530021,China;不详)

机构地区：[1]广西医科大学公共卫生学院,广西南宁530021 [2]柳州市疾病预防控制中心办公室 [3]北京大学公众健康与重大疫情防控战略研究中心 [4]北京大学公共卫生学院流行病与卫生统计学系 [5]重大疾病流行病学教育部重点实验室(北京大学) [6]柳州市疾病预防控制中心慢病防制与健康促进所

出　　处：《环境与健康杂志》2024年第8期675-680,共6页Journal of Environment and Health

基　　金：国家自然科学基金(82192900,82192901,82192904,81390540,91846303);国家重点研发计划精准医学研究重点专项(2016YFC0900500);香港Kadoorie Charitable基金;英国Wellcome Trust(202922/Z/16/Z,088158/Z/09/Z,104085/Z/14/Z)。

摘　　要：目的探讨柳州市环境大气污染物一氧化碳(CO)暴露与缺血性心脏病发病风险的关系。方法基于中国慢性病前瞻性研究队列(CKB)的柳州子队列,构建时间序列的分布滞后非线性模型,分析大气污染物与缺血性心脏病发病风险之间的关联。结果CO暴露与缺血性心脏病发病风险的关联有统计学意义,CO每升高1 mg/m^(3),单日滞后(lag1)效应最大,缺血性心脏病发病风险增加1.102%(95%CI:1.010%~1.202%);累积滞后(lag03)效应最大,缺血性心脏病发病风险增加1.375%(95%CI:1.038%~1.821%)。CO、SO_(2)和NO_(2)对缺血性心脏病发病风险的影响在冷季时更为明显,≥60岁、体育锻炼≥3次/周和退休人群更易受到CO的影响。结论大气污染物CO暴露可能增加缺血性心脏病的发病风险。有必要采取措施降低大气CO的浓度,从而降低缺血性心脏病的发生风险。Objective To understand the relationship between atmospheric pollutantsexposure,including carbon monoxide(CO),sulfur dioxide(SO_(2)),nitrogen dioxide(NO_(2))and the risk of ischemic heart disease(IHD).Methods Using the Liuzhou sub-cohort from the China Kadoorie Biobank(CKB)Prospective Study,a time-series distributed lag nonlinear model was constructed to analyze the association between atmospheric pollutants and the risk of IHD.Results The association between CO exposure and theincidence of IHD was statistically significant.With a 1 mg/m^(3)increase in CO concentration,the maximum single-day lag effect was associated with a 1.102%increase in IHD risk(95%CI:1.010%-1.202%,lag 1 day),and the maximum cumulative lag effect was associated with a 1.375%increase in IHD risk(95%CI:1.038%-1.821%,lag 03 days).The effects of CO,SO_(2) and NO_(2) on IHD risk were more pronounced during the cold season,and individuals aged≥60,engaging in physical exercise≥3 times per week,and retirees were more susceptible to the impact of CO.Conclusion Exposure to the air pollutant CO may increase the risk of IHD.It is necessary to take measures to reduce CO concentration in order to decrease the risk of IHD.

关 键 词：大气污染 缺血性心脏病 时间序列 

分 类 号：R122.2[医药卫生—环境卫生学] R181.3[医药卫生—公共卫生与预防医学]