Hippo信号通路在肺纤维化中的调控机制研究进展  

Research progress on the regulatory mechanism of Hippo signaling pathway in pulmonary fibrosis

作　　者：丁锐黠 孙莹 王晓晖 Ding Ruixia;Sun Ying;Wang Xiaohui(School of Public Health,Baotou Medical College,Inner Mongolia University of Science&Technology,Baotou 014040,China)

机构地区：[1]内蒙古科技大学包头医学院公共卫生学院,包头014040

出　　处：《中华劳动卫生职业病杂志》2024年第9期716-720,共5页Chinese Journal of Industrial Hygiene and Occupational Diseases

基　　金：内蒙古自治区自然科学基金项目(2020BS08004);包头医学院科学研究基金项目自然科学类青苗计划项目(BYJJ-ZRQM 202316);2024年校内专项-2024年校级研究生科研创新项目(BYKYCX 202412)。

摘　　要：肺纤维化是一种难治性纤维化疾病,诱发因素多,发病机制复杂,以弥漫性炎症损伤、组织结构破坏、持续性纤维化为特征,造成肺功能不可逆性破坏。Hippo信号通路参与调控细胞增殖、分化、迁移和凋亡等多种生物学过程,与肺纤维化的发生密切相关。为进一步探索肺纤维化机制,本文通过对Hippo信号通路及其与肺纤维化相关的细胞和病理性失衡现象进行综合分析,揭示Hippo信号通路在肺纤维化中的影响以及可能的作用机制,有望为肺纤维化的防治提供新的靶点和策略。Pulmonary fibrosis is a difficult to treat fibrotic disease with multiple triggering factors and complex pathogenesis.It is characterized by diffuse inflammatory damage,tissue structure destruction,and persistent fibrosis,resulting in irreversible damage to lung function.The Hippo signaling pathway is involved in regulating various biological processes such as cell proliferation,differentiation,migration,apoptosis,and is closely related to the occurrence of pulmonary fibrosis.In order to further explore the mechanism of pulmonary fibrosis,this paper comprehensively analyzes the Hippo signaling pathway and its cellular and pathological imbalance related to pulmonary fibrosis,revealing the influence of Hippo signaling pathway in pulmonary fibrosis and its possible mechanism of action,which is expected to provide new targets and strategies for the prevention and treatment of pulmonary fibrosis.

关 键 词：肺纤维化 Hippo信号通路 致病机制 成纤维细胞 YAP/TAZ 

分 类 号：R563[医药卫生—呼吸系统]