Upconversion-based chiral nanoprobe for highly selective dual-mode sensing and bioimaging of hydrogen sulfide in vitro and in vivo  

作　　者：Yang Lu Xu Zhao Dongmei Yan Yingqian Mi Peng Sun Xu Yan Xiaomin Liu Geyu Lu 

机构地区：[1]State Key Laboratory of Integrated Optoelectronics,College of Electronic Science and Engineering,Jilin University,130012 Changchun,China [2]Department of Immunology,College of Basic Medical Sciences,Jilin University,130021 Changchun,China

出　　处：《Light(Science & Applications)》2024年第9期1878-1887,共10页光（科学与应用)（英文版）

基　　金：supported by the National Key R&D Program of China(No.2023YFB3208303);The National Natural Science Foundation of China(No.62171194);Natural Science Foundation of Jilin Province(No.20210101380JC,20220204130YY and 20230204082YY).

摘　　要：Chiral assemblies have become one of the most active research areas due to their versatility,playing an increasingly important role in bio-detection,imaging and therapy.In this work,chiral UCNPs/CuxOS@ZIF nanoprobes are prepared by encapsulating upconversion nanoparticles(UCNPs)and CuxOS nanoparticles(NPs)into zeolitic imidazolate framework-8(ZIF-8).The novel excited-state energy distribution-modulated upconversion nanostructure(NaYbF4@-NaYF4:Yb,Er)is selected as the fluorescence source and energy donor for highly efficient fluorescence resonance energy transfer(FRET).CuxOS NP is employed as chiral source and energy acceptor to quench upconversion luminescence(UCL)and provide circular dichroism(CD)signal.Utilizing the natural adsorption and sorting advantages of ZIF-8,the designed nanoprobe can isolate the influence of other common disruptors,thus achieve ultra-sensitive and highly selective UCL/CD dual-mode quantification of H2S in aqueous solution and in living cells.Notably,the nanoprobe is also capable of in vivo intra-tumoral H2S tracking.Our work highlights the multifunctional properties of chiral nanocomposites in sensing and opens a new vision and idea for the preparation and application of chiral nanomaterials in biomedical and biological analysis.

关 键 词：CHIRAL sulfide DONOR 

分 类 号：O62[理学—有机化学]