膜仿生纳米载体在肺部疾病靶向治疗中应用研究进展  

Research progress on the application of membrane biomimetic nanocarriers in targeted therapy of lung diseases

作　　者：白文静 郭蓉 熊淋 朱冷静 李嘉欣 王雅施 李曼[1] 何勤[1] BAI Wen-jing;GUO Rong;XIONG Lin;ZHU Leng-jing;LI Jia-xin;WANG Ya-shi;LI Man;HE Qin(Key Laboratory of Drug Targeting and Drug Delivery Systems,Ministry of Education,West China School of Pharmacy,Sichuan University,Chengdu 610041,China;West China School of Basic Medical Sciences and Forensic Medicine,Sichuan University,Chengdu 610041,China)

机构地区：[1]四川大学华西药学院,靶向药物及释药系统教育部重点实验室,四川成都610041 [2]四川大学华西基础医学与法医学院,四川成都610041

出　　处：《药学学报》2024年第10期2730-2740,共11页Acta Pharmaceutica Sinica

基　　金：国家自然科学基金资助项目(82173761);四川省科技项目(2022NSFSC0045)。

摘　　要：肺部疾病是人类健康的主要威胁之一,目前针对肺部疾病的临床治疗药物普遍存在肺部递送效率低、清除速率快及毒副作用明显等问题。近年来,膜仿生纳米载体受到越来越多的关注,因其具有靶向性高、循环时间长、生物相容性好和免疫逃逸能力强等优势,已成为肺部疾病靶向治疗的一大研究热点。本文综述了膜仿生纳米粒的主要制备方法、不同细胞来源的膜仿生纳米载体的特点及其在肺部疾病靶向治疗中的应用;此外,结合不同膜的性质特点分别讨论其缺点,并讨论当前的技术局限性及未来的展望,为膜仿生纳米载体的设计及其在肺部疾病治疗中的潜在应用提供参考。Pulmonary disease is one of the major threats to human health.However,the current clinical treatment drugs for lung diseases generally have problems such as low lung delivery efficiency,fast clearance rate and obvious toxic side effects.Recently,membrane biomimetic nanocarriers have attracted more and more attention.Due to their advantages of high targeting,long cycle time,good biocompatibility and strong immune escape ability,membrane biomimetic nanocarriers have become a major research hotspot in targeted therapy of lung diseases.In this review,we discuss the main preparation methods of membrane biomimetic nanoparticles,the characteristics of membrane biomimetic nanocarriers from different cell sources and their application in the targeted therapy of lung diseases.At the same time,according to the characteristics of different membranes,the shortcomings,current technical limitations and future prospects are discussed.This review is expected to provide references for the design of membrane biomimetic nanocarriers and their potential applications in the treatment of lung diseases.

关 键 词：肺部疾病 肺靶向 细胞膜 膜仿生纳米载体 药物递送系统 

分 类 号：R943[医药卫生—药剂学]