DNA折纸智能药物递送系统的研究进展  

Advances in DNA origami intelligent drug delivery systems

作　　者：殷曾琳 王曦维 车津晶 刘楠 张慧 王增明 李见春 郑爱萍 YIN Zeng-lin;WANG Xi-wei;CHE Jin-jing;LIU Nan;ZHANG Hui;WANG Zeng-ming;LI Jian-chun;ZHENG Ai-ping(School of Pharmacy,Bengbu Medical University,Bengbu 233030,China;State Key Laboratory of National Security Specially Needed Medicines,Academy of Military Medical Sciences,Beijing 100850,China)

机构地区：[1]蚌埠医科大学药学院,安徽蚌埠233030 [2]军事医学研究院国家安全特需药品全国重点实验室,北京100850

出　　处：《药学学报》2024年第10期2741-2750,共10页Acta Pharmaceutica Sinica

基　　金：国家资助博士后研究人员C档(GZC20233575);军队后勤科研重点项目(BWS21T015)。

摘　　要：DNA折纸术是一种产生具有动态特性和智能可控纳米结构的强大技术。精确的几何形状、高度可编程性及优异的生物相容性使得DNA折纸纳米结构成为一种新兴的药物递送载体。载体材料的形状、大小及药物的负载和释放是影响药物生物利用度的重要因素。本文着重介绍了可控设计DNA折纸纳米结构、高效负载药物及智能释放药物,归纳总结了DNA折纸技术在生物医学中的前沿应用,最后讨论了研究人员可以在哪些方面为进一步推进DNA折纸载体的临床应用作出贡献。DNA origami is a powerful technique for generating nanostructures with dynamic properties and intelligent controllability.The precise geometric shapes,high programmability,and excellent biocompatibility make DNA origami nanostructures an emerging drug delivery vehicle.The shape,size of the carrier material,as well as the loading and release of drugs are important factors affecting the bioavailability of drugs.This paper focuses on the controllable design of DNA origami nanostructures,efficient drug loading,and intelligent drug release.It summarizes the cutting-edge applications of DNA origami technology in biomedicine,and discusses areas where researchers can contribute to further advancing the clinical application of DNA origami carriers.

关 键 词：DNA折纸 可编程性 药物递送 可控设计 生物医学 

分 类 号：R943[医药卫生—药剂学]