苏合香中一个新的松香烷二萜  

A new abietane diterpene from the Styrax

作　　者：冯结楠 程永现 FENG Jie-nan;CHENG Yong-xian(School of Pharmacy,Guangdong Pharmaceutical University,Guangzhou 510006,China;Guangdong Key Laboratory of Chinese Medicine Ingredients and Gut Microbiomics,Institute for Inheritance-Based Innovation of Chinese Medicine,School of Pharmacy,Shenzhen University Medical School,Shenzhen University,Shenzhen 518060,China)

机构地区：[1]广东药科大学药学院,广东广州510006 [2]广东省中药有效成分与肠道微生物组学重点实验室,深圳大学中医药守正创新研究院,深圳大学医学部药学院,广东深圳518060

出　　处：《药学学报》2024年第10期2836-2841,共6页Acta Pharmaceutica Sinica

摘　　要：运用MCI Gel CHP 20P、Sephadex LH-20、ODS和硅胶等柱色谱,结合TLC、半制备液相色谱等分离纯化方法,从苏合香水提物的95%乙醇溶解物中得到12个松香烷二萜化合物。运用1D、2D NMR、UV、MS等现代波谱学方法对所分离得到的化合物进行结构鉴定,并运用计算ECD的方法确定了新化合物的绝对构型。其中,化合物1为新化合物,鉴定为(4R,5R,9S,10R,12S)-12-methoxy-neoabietic acid,化合物2~12为首次从苏合香中分离得到。Twelve abietane diterpenes were isolated from the 95%ethanol fraction solvated from the aqueous extract of Styrax by using various chromatographic methods,including MCI Gel CHP 20P,Sephadex LH-20,ODS,silica gel,TLC and semi-preparative HPLC.The structures of the isolated compounds were identified by spectroscopy methods(1D,2D NMR,UV,MS,etc.),and the absolute configuration of the new compound was determined by ECD calculations.Compound 1 is a new compound,which was identified as(4R,5R,9S,10R,12S)-12-methoxy-neoabietic acid,and compounds 2−12 were isolated from Styrax for the first time.

关 键 词：苏合香 树脂 松香烷型二萜 提取分离 结构鉴定 

分 类 号：R284[医药卫生—中药学]