神经内分泌肿瘤患者接受长效生长抑素类似物治疗引起胆道结石的相关因素分析  

Analysis of factors related to gallstone formation in patients with neuroendocrine tumors treated with long-acting somatostatin analogues

作　　者：祁志荣 王超 陈莹莹 程志强[1] 谭煌英[1] QI Zhi-rong;WANG Chao;CHEN Ying-ying(Department of Integrative Oncology,China-Japan Friendship Hospital,Beijing 100029,China)

机构地区：[1]中日友好医院、中西医结合肿瘤内科,北京100029 [2]北京中医药大学,北京100029

出　　处：《中日友好医院学报》2024年第5期259-263,共5页Journal of China-Japan Friendship Hospital

基　　金：国家自然科学基金(81673763,82074224)。

摘　　要：目的:探讨生长抑素类似物(SSA)治疗神经内分泌肿瘤(NENs)引起胆道结石的发病情况及相关因素。方法:收集我科2010年—2022年期间使用SSA治疗NENs患者的资料,进行回顾分析。对患者的人口学特征和疾病特征进行分析,评价其胆道结石的发病率及影响因素。结果:83例接受SSA患者中,60例无胆道结石病史,26例(43.3%)在治疗开始后平均18.5个月(范围3~94个月)出现胆道结石,胆道结石发生与接受SSA治疗的持续时间相关(OR:1.03,95%CI:1.01~1.05,P<0.05)。11例已切除胆囊的患者中只有1例(9.1%)发生胆道结石,胆囊切除者的胆道结石发生率下降。结论:SSA治疗NENs引起胆道结石的发生率较高,SSA治疗时间长短可能与胆道结石发生相关。Objective:To evaluate the incidence and associated factors of gallstone formation in a series of patients treated with long-acting somatostatin analogs(SSA)for neuroendocrine neoplasms.Methods:A prospectively-collected database of patients with a diagnosis of neuroendocrine neoplasms,treated with somatostatin analogs at our institution between 2010 and 2022 was retrospectively analyzed.Patients'demographics and disease characteristics were analyzed to evaluate the incidence and the factors related to biliary stone formation.Results:Eighty-three patients were included,among them 60 with gallbladder in situ and no history of stone disease,26(43.3%)developed gallstones after a mean of 18.5months(range 3~94)treatment period.The incidence of gallstone is related to duration of receiving somatostatin analogs treatment(OR:1.03,95%CI:1.01~1.05,P<0.05).Previous cholecystectomy was associated with a lower incidence of gallstone formation.Among 11 patients who underwent cholecystectomy before the start of SSA,1(9.1%)patient developed common bile duct stones during SSA therapy.Conclusion:We observed a high incidence of gallstone disease in patients treated with long-acting SSA-treated for neuroendocrine neoplasm,SSA treatment duration is probably related to the occurrence of gallstone formation.

关 键 词：神经内分泌肿瘤 生长抑素类似物 胆道结石 

分 类 号：R459.1[医药卫生—治疗学]