豪洛捷乳腺结节真空旋切术对乳腺结节患者5-HT MDA及TNF-α的影响  

Effect of vacuum Rotary Excision of Breast Nodules in Patients with Breast Nodules with 5-HT MDA and TNF-αby Haurologie

作　　者：王静[1] 周煜栋 郭萍利[1] WANG Jing;ZHOU Yudong;GUO Pingli(The First Affiliated Hospital of Xi'an Jiaotong University,Shaanxi Xi'an 710061,China)

机构地区：[1]西安交通大学第一附属医院乳腺外科,陕西西安710061

出　　处：《河北医学》2024年第10期1639-1644,共6页Hebei Medicine

基　　金：陕西省自然科学基础研究计划项目,(编号:2019JM-553)。

摘　　要：目的:探讨豪洛捷乳腺结节真空旋切术对乳腺结节患者神经递质5-羟色胺(5-hydroxytryptamine,5-HT)、丙二醛(Malondialdehyde,MDA)及肿瘤坏死因子-α(Tumor necrosis factor-α,TNF-α)的影响。方法:回顾性分析择取2020年4月至2023年5月期间,本院收治的乳腺结节患者148例,经纳入、排除标准剔除46例病例,最终纳入102例病例,依据手术方式不同分为对照组(n=50,传统小切口术治疗)及实验组(n=52,豪洛捷乳腺结节真空旋切术治疗)。对比两组手术观察指标、治疗前后5-HT、MDA及TNF-α水平变化、术后恢复良好率、并发症发生率及结节复发率。结果:与对照组相比较,实验组切口长度更短,术后住院天数、失血量更少,手术总时长更短(P<0.05)。治疗前至治疗后3d的5-HT、MDA及TNF-α水平均上升,治疗后3d至治疗后7d的5-HT、MDA及TNF-α水平均下降(P<0.05),且在治疗后1d、3d、7d时,实验组5-HT、MDA及TNF-α水平比对照组低(P<0.05)。对照组、实验组恢复良好率分别为78.00%、92.31%,实验组恢复良好率更高(P<0.05)。两组结节复发率比较,差异无统计学意义(P>0.05),实验组并发症发生率(5.76%)比对照组(20.00%)低(P<0.05)。结论:豪洛捷乳腺结节真空旋切术对乳腺结节患者5-HT、MDA及TNF-α水平影响相对较小,且并发症发生率低,在促进患者术后早期康复中有积极作用。Objective:To investigate the effects of Haurologic breast nodule vacuum rotary excision on neurotransmitters 5-hydroxytryptamine(5-HT),malondialdehyde(MDA)and tumor necrosis factor-α(TNF-α)in patients with breast nodules.Methods:A retrospective analysis was performed on 148 patients with breast nodules admitted to our hospital from April 2020 to May 2023.46 cases were excluded by inclusion and exclusion criteria,and 102 cases were finally included.According to different surgical methods,they were divided into control group(n=50,traditional small incision treatment)and experimental group(n=52,Holloway vacuum rotary resection of breast nodules).The surgical observation indexes,the changes of 5-HT,MDA and TNF-αlevels before and after treatment,the good rate of postoperative recovery,the incidence of complications,and the recurrence rate of nodules were compared between the two groups.Results:The total operation time of the experimental group was shorter than that of the control group,the incision length was shorter,the amount of blood loss and the total postoperative hospitalization days were less than that of the control group(P<0.05).The levels of 5-HT,MDA and TNF-αincreased from before treatment to 3 days after treatment,and the levels of 5-HT,MDA,and TNF-αdecreased from 3 days after treatment to 7 days after treatment(P<0.05).The levels of 5-HT,MDA and TNF-αin the experimental group were lower than those in the control group at 1 day,3 days,and 7 days after treatment(P<0.05).The good recovery rates of control group and experimental group were 78.00%and 92.31%,respectively,and the rate of good recovery was higher in the experimental group(P<0.05).When comparing the recurrence rate of nodules in the two groups,the difference was not statistically significant(P>0.05),and the total complication rate of the experimental group(5.76%)was lower than that of the control group(20.00%)(P<0.05).Conclusion:Halotiere vacuum rotation of breast nodules has relatively little effect on the levels of 5-HT,MDA and TNF-αin pa

关 键 词：豪洛捷乳腺结节真空旋切术 乳腺结节 5-羟色胺 丙二醛 肿瘤坏死因子-α 

分 类 号：R655.8[医药卫生—外科学]