CTRP-3 CTRP12水平与慢性阻塞性肺疾病GOLD分级及预后的相关性研究  

Correlation between CTRP-3 CTRP-12 Levels and GOLD Grading and Prognosis of Chronic Obstructive Pulmonary Disease

作　　者：王明 丁国正 吕志芳 WANG Ming;DING Guozheng;LV Zhifang(Anqing Hospital of Anhui Medical University,Anhui Anqing 246000,China)

机构地区：[1]安徽医科大学附属安庆医院/安庆市立医院呼吸与危重症医学科,安徽安庆246000

出　　处：《河北医学》2024年第10期1685-1689,共5页Hebei Medicine

基　　金：2022年度安徽省卫生健康科研项目,(编号:AHWJ2022b099);安庆市卫生健康委科研课题,(编号:AQWJ2023001)。

摘　　要：目的:分析C1q肿瘤坏死因子相关蛋白3(CTRP-3),肿瘤坏死因子相关蛋白12(CTRP12)水平与慢性阻塞性肺疾病(COPD)全球倡议(GOLD)分级及预后的相关性。方法:选取本院2022年9月至2024年1月收治的126例COPD患者作为病例组,选取同时期入院体检且健康的90例志愿者为对照组,比较两组临床资料和血清CTRP-3,CTRP12水平,依据全球倡议(GOLD)分级将患者分为Ⅰ级组(n=9)、Ⅱ级组(n=21)、Ⅲ级组(n=43)和Ⅳ级组(n=53),对比四组患者CTRP-3,CTRP12水平;记录病例组预后情况,并比较不同预后患者CTRP-3,CTRP12水平;采用Pearson相关性分析探讨临床指标与血清CTRP-3、CTRP12水平的相关性。结果:两组年龄、性别、体质量指数、吸烟史及基础疾病比较,差异均无统计学意义(P>0.05);病例组患者WBC高于对照组(P<0.05),FEV1、FEV1/FVC均低于对照组(P<0.05)。病例组CTRP-3、CTRP12水平均低于对照组(P<0.05)。不同GOLD分级COPD患者组间CTRP-3、CTRP12水平比较差异有统计学意义(P<0.05);CTRP-3、CTRP12水平比较均为Ⅰ级组>Ⅱ级组>Ⅲ级组>Ⅳ级组(P<0.05)。预后良好组CTRP-3、CTRP12水平均高于预后不良组(P<0.05)。相关性分析显示:COPD患者血清中CTRP-3水平与吸烟史及GOLD分级均呈负相关(P<0.05),与FEV1/FVC水平呈正相关(P<0.05);CTRP12水平与吸烟史、WBC、GOLD分级均呈负相关(P<0.05),与FEV1/FVC水平呈正相关(P<0.05)。CTRP-3、CTRP12水平与COPD病程、住院时间及FEV1均无相关性(P>0.05)。结论:COPD患者血清中CTRP-3、CTRP12水平低于健康者,且与吸烟史、GOLD分级均成负相关,与FEV1/FVC水平呈正相关。Objective:To analyze the correlation between levels of C1q tumor necrosis factor-related protein 3(CTRP-3)and C1q tumor necrosis factor-related protein 12(CTRP12)and global initiative(GOLD)grading and prognosis of chronic obstructive pulmonary disease(COPD).Methods:A total of 126 patients with COPD in the hospital were selected from September 2022 to January 2024 and included in the case group,and 90 healthy volunteers receiving physical examination were assigned into the control group.The clinical data and serum CTRP-3 and CTRP12 levels were compared between both groups.According to the GOLD grading,COPD patients were classified into grade I group(n=9),gradeⅡgroup(n=21),gradeⅢgroup(n=43)and grade IV group(n=53).The levels of CTRP-3 and CTRP12 among the four groups were compared.The prognosis in the case group was recorded,and the CTRP-3 and CTRP12 levels were compared among patients with different prognosis status.Pearson correlation analysis was adopted to explore the correlation between clinical indicators and levels of serum CTRP-3 and CTRP12.Results:The age,gender,body mass index,smoking history and underlying diseases between the two groups manifested no statistical differences(P>0.05).WBC in the case group was higher(P<0.05)while FEV1 and FEV1/FVC were lower than those in the control group(P<0.05).The levels of CTRP-3 and CTRP12 were lower in the case group(P<0.05).There were statistical differences in the levels of CTRP-3 and CTRP12 among COPD patients with different GOLD grades(P<0.05).CTRP-3 and CTRP12 levels were manifested as grade I group>gradeⅡgroup>gradeⅢgroup>grade IV group(P<0.05).Compared with the poor prognosis group,the levels of CTRP-3 and CTRP12 in the good prognosis group were higher(P<0.05).Correlation analysis showed that serum CTRP-3 level in COPD patients was negatively correlated with smoking history and GOLD grading(P<0.05),and was positively associated with FEV1/FVC(P<0.05).CTRP12 level was negatively correlated with smoking history,WBC and GOLD grading(P<0.05),and was positi

关 键 词：C1q肿瘤坏死因子相关蛋白3 肿瘤坏死因子相关蛋白12 慢性阻塞性肺疾病 GOLD分级 预后 相关性 

分 类 号：R563.9[医药卫生—呼吸系统]