感染所致急性肾损伤老年患者NEU/ALB血流动力学免疫球蛋白水平与肾功能转归的关系研究  

Relationship between NEU/ALB Hemodynamics,Immunoglobulins and Renal Function Outcome in Elderly Patients with Infection-Induced Acute Kidney Injury

作　　者：谢娟 倪刚 潘亚超 王羊洋 XIE Juan;NI Gang;PAN Yachao(Hefei First People's Hospital,Anhui Hefei 230000,China)

机构地区：[1]安徽省合肥市第一人民医院,安徽合肥230000

出　　处：《河北医学》2024年第10期1722-1727,共6页Hebei Medicine

基　　金：安徽省健康发展战略研究中心资政项目,(编号:2023szk001)。

摘　　要：目的:探讨感染所致急性肾损伤老年患者中性粒细胞(NEU)/白蛋白(ALB)、血流动力学、免疫球蛋白水平与肾功能转归的关系。方法:选取我院2021年1月至2023年12月收治的117例感染所致急性肾损伤老年患者为研究对象,入院时均进行NEU、ALB、血流动力学和免疫球蛋白检测,患者采用综合对症治疗,根据其肾功能转归情况将患者分为转归良好组和转归不良组,对比两组NEU/ALB、血流动力学、免疫球蛋白水平,采用多因素Logistic回归分析感染所致急性肾损伤老年患者肾功能转归的影响因素。结果:转归良好组性别、年龄、体质指数(BMI)、尿蛋白与转归不良组比较差异无统计学意义(P>0.05),血清肌酐水平低于转归不良组(P<0.05)。转归良好组NEU、NEU/ALB水平均低于转归不良组(P<0.05),ALB和IgG、IgM水平均高于转归不良组(P<0.05),MAP、CI均大于转归不良组(P<0.05),HR、IgA水平与转归不良组比较差异无统计学意义(P>0.05)。多因素Logistic回归分析,结果显示NEU/ALB、MAP、CI、IgG均是感染所致急性肾损伤老年患者肾功能转归的影响因素(P<0.05)。结论:感染所致急性肾损伤老年患者NEU/ALB、血流动力学、免疫球蛋白水平与其肾功能转归存在相关性,检测上述指标有利于评估患者肾功能转归情况。Objective:To investigate the relationship of neutrophil(NEU)/albumin(ALB),hemodynamics and immunoglobulins levels with renal function outcome in elderly patients with infection-induced acute kidney injury(AKI).Methods:Totally 117 elderly patients with infection-induced AKI in the hospital were selected from January 2021 to December 2023 as the research subjects.NEU,ALB,hemodynamics and immunoglobulin were detected at admission.The patients were treated with comprehensive symptomatic treatment and were divided into good outcome group and poor outcome group according to the outcome of renal function.The levels of NEU/ALB,hemodynamics and immunoglobulins were compared between groups.Multivariate Logistic regression analysis was used to analyze the influencing factors of renal function outcome in elderly patients with infection-induced AKI.Results:There were no statistical differences in gender,age,body mass index(BMI)and urinary protein between the good outcome group and the poor outcome group(P>0.05),but serum creatinine level was lower than that in the poor outcome group(P<0.05).NEU and NEU/ALB in the good outcome group were lower than those in the poor outcome group(P<0.05)while ALB,IgG and IgM levels were higher(P<0.05),and MAP and CI were higher than those in the poor outcome group(P<0.05),but the HR and IgA were not statistically different compared with those in the poor outcome group(P>0.05).Multivariate Logistic regression analysis showed that NEU/ALB,MAP,CI and IgG were influencing factors of renal function outcome in elderly patients with infection-induced AKI(P<0.05).Conclusion:The NEU/ALB,hemodynamics and immunoglobulins levels are correlated with renal function outcome in elderly patients with infection-induced acute kidney injury.The detection of the above indicators is helpful to evaluate the renal function outcome of patients.

关 键 词：急性肾损伤 感染 中性粒细胞 清蛋白 血流动力学 免疫球蛋白 

分 类 号：R692[医药卫生—泌尿科学]