血培养阳性报警时间联合PCT、CRP在细菌性血流感染中的诊断价值研究  

Study on the diagnosis value of blood culture positive alarm time combined with PCT and CRP in bacterial bloodstream infection

作　　者：程宜[1] 王琳[1] 马小宏 CHENG Yi;WANG Lin;MA Xiaohong(Department of Laboratory Medicine,Rugao People′s Hospital,Nantong,Jiangsu 226500,China)

机构地区：[1]如皋市人民医院检验科,江苏南通226500

出　　处：《现代医药卫生》2024年第20期3490-3493,共4页Journal of Modern Medicine & Health

摘　　要：目的研究血培养阳性报警时间(TTP)联合降钙素原(PCT)、C反应蛋白(CRP)在细菌性血流感染(BSI)中的诊断价值。方法选取该院从2022年1月至2023年6月收治的700例细菌性BSI患者开展试验,作为感染组;另选取同期判定为血培养污染患者100例作为对照组。检测并对比分析2组患者TTP与PCT、CRP水平。对比不同检测方式诊断细菌性BSI的效能。此外,对比不同种类病原菌感染及不同感染程度患者TTP与PCT、CRP水平。结果感染组患者TTP为(12.66±3.43)h,短于对照组的(20.11±5.19)h,而血清PCT、CRP水平分别为(1.79±0.42)ng/mL、(41.73±7.55)mg/L,均高于对照组[(0.03±0.01)ng/mL、(3.55±1.01)mg/L],差异均有统计学意义(P<0.05)。将血培养结果作为“金标准”,TTP与PCT、CRP联合检测诊断细菌性BSI的灵敏度、特异度、准确度分别为91.00%、97.00%、91.75%,均高于上述三项指标单独诊断,差异均有统计学意义(P<0.05)。革兰阳性菌感染患者PCT水平低于革兰阴性菌感染患者,差异有统计学意义(P<0.05);不同种类病原菌感染患者TTP与CRP水平比较,差异均无统计学意义(P>0.05)。重度感染患者PCT、CRP水平均高于轻中度感染患者,差异均有统计学意义(P<0.05)。结论TTP联合PCT、CRP诊断细菌性BSI的效能较佳,且能有效鉴别病原菌类型,为患者感染严重程度的评估提供可靠依据。Objective To study the diagnosis value of blood culture positive alarm time(TTP)combined with procalcitonin(PCT)and C-reactive protein(CRP)in bacterial bloodstream infection(BSI).Methods A total of 700 patients with bacterial BSI admitted to the hospital from January 2022 to June 2023 were selected for the experiment and as the infection group.Another 100 cases identified as blood culture contamination during the same period were selected as the control group.Detecting and comparing the levels of TTP,PCT,and CRP in two groups,and comparing the efficacy of different detection methods in diagnosing bacterial BSI.In addition,comparing the levels of TTP,PCT,and CRP in patients with different types of pathogen infections and varying degrees of infection.Results The TTP of the infected group was(12.66±3.43)h,which was shorter than that of the control group[(20.11±5.19)h],while the serum PCT and CRP levels were(1.79±0.42)ng/mL and(41.73±7.55)mg/L,respectvely,both higher than those of the control group[(0.03±0.01)ng/mL and(3.55±1.01)mg/L],with statistically significant differences(P<0.05).Using blood culture results as the“gold standard”,the sensitivity,specificity,and accuracy of TTP combined with PCT and CRP in diagnosing bacterial BSI were 91.00%,97.00%,and 91.75%,respectively,which were higher than those of the above three indicators separately,and the differences were statistically significant(P<0.05).The PCT level of Gram-positive bacteria infected patients was lower than that of Gram-negative bacteria infected patients(P<0.05),and the differences were statistically significant(P<0.05).There was no statistically significant difference in TTP and CRP levels among patients infected with different types of pathogens(P>0.05).The levels of PCT and CRP in patients with severe infection were higher than those in patients with mild to moderate infection,the differences were statistically significant(P<0.05).Conclusion TTP combined with PCT and CRP has better efficacy in the diagnosis of bacterial BSI,and can effe

关 键 词：细菌性血流感染 血培养 降钙素原 C反应蛋白 诊断效能 

分 类 号：R378[医药卫生—病原生物学]