木丹颗粒辅助治疗对糖尿病周围神经病变患者神经传导速度及TCSS评分的影响  

Effect of Mudan granule adjuvant therapy on nerve conduction velocity and TCSS score in patients with diabetic peripheral neuropathy

作　　者：杨海燕[1] 金海 YANG Haiyan;JIN Hai(Fengcheng People′s Hospital,Yichun,Jiangxi 331100,China)

机构地区：[1]丰城市人民医院,江西宜春331100

出　　处：《现代医药卫生》2024年第20期3498-3501,共4页Journal of Modern Medicine & Health

摘　　要：目的观察木丹颗粒辅助治疗对糖尿病周围神经病变(DPN)患者神经传导速度及多伦多临床神经病变评分(TCSS评分)的影响。方法选择2022年5月至2023年6月该院收治的DPN患者86例作为研究对象,依据随机数字表法将其分为对照组和观察组,各43例。2组患者均接受常规降血糖治疗,对照组给予硫辛酸治疗,在此基础上观察组给予木丹颗粒治疗,均连续治疗4周。比较2组患者感觉神经传导速度、TCSS评分及不良反应。结果治疗后2组患者正中神经、腓浅神经、腓深神经传导速度较治疗前提高,且观察组提高更显著,差异均有统计学意义(P<0.05);治疗后2组患者神经症状、感觉、反射评分均较治疗前降低,且观察组降低更显著,差异均有统计学意义(P<0.05);治疗后,2组患者全血低切黏度、全血高切黏度、血浆黏度及纤维蛋白原均较治疗前降低,且观察组较对照组低,差异均有统计学意义(P<0.05);2组患者不良反应发生率比较,差异无统计学意义(χ^(2)=0.104,P=0.747)。结论木丹颗粒辅助治疗可改善DPN患者血液循环,促进周围神经症状的改善,提高神经传导速度,且辅助治疗安全性较高,临床上可推广应用。Objective To observe the effect of Mudan granule on nerve conduction velocity and Toronto Clinical Neuropathy Score(TCSS score)in patients with diabetic peripheral neuropathy(DPN).Methods A total of 86 patients with DPN admitted to this hospital from May 2022 to June 2023 were selected as the research object,and they were randomly divided into control group and observation group,with 43 cases in each group.Both groups received routine hypoglycemic therapy,while the control group was treated with lipoic acid.On this basis,the observation group was treated with Mudan granule,both for 4 weeks.Sensory nerve conduction velocity,TCSS score and adverse reactions were compared between the two groups.Results After treatment,the conduction velocity of median nerve,superficial peroneal nerve and deep peroneal nerve in the two groups increased,and the improvement in the observation group was more significant,with statistical significance(P<0.05).After treatment,the scores of neurological symptoms,sensation and reflex in both groups decreased,especially in the observation group,with statistical significance(P<0.05).After treatment,the whole blood low shear viscosity,whole blood high shear viscosity,plasma viscosity and fibrinogen in the two groups decreased,especially in the observation group,and the differences were statistically significant(P<0.05).There was no significant difference in the incidence of adverse reactions between the two groups(χ^(2)=0.104,P=0.747).Conclusion Adjuvant therapy with Mudan granule can improve the blood circulation of DPN patients,promote the improvement of peripheral nerve symptoms,and increase the nerve conduction velocity.Adjuvant therapy is safe and can be widely used in clinic.

关 键 词：糖尿病周围神经病变 木丹颗粒 硫辛酸 神经传导 TCSS评分 

分 类 号：R587.2[医药卫生—内分泌]