参附注射液联合西药治疗老年急性心肌梗死合并心源性休克对患者左心室收缩功能及预后的影响  

The Effect of Reference Injection and Western Medicine on Elderly Acute Myocardial Infarction Combined with Cardiogenic Shock on Left Ventricular Systolic Function and Prognosis

作　　者：阮梦瑶 王盼盼 RUAN Mengyao;WANG Panpan(Zhengzhou Hospital of Traditional Chinese Medicine,Henan Zhengzhou 450000,China)

机构地区：[1]河南省郑州市中医院,河南郑州450000

出　　处：《中医药临床杂志》2024年第10期1939-1943,共5页Clinical Journal of Traditional Chinese Medicine

摘　　要：目的:探讨参附注射液联合西药治疗老年急性心肌梗死合并心源性休克对患者左心室收缩功能及预后的影响。方法:根据随机数字表法,2021年1月—2023年1月郑州市中医院就诊的77例老年急性心肌梗死合并心源性休克患者分为对照组(39例)和观察组(38例)。对照组行常规西药疗法,观察组则在对照组的治疗基础上加以参附注射液,两组均连续治疗一周。比较两组临床疗效,治疗前后的平均动脉压、收缩压、中心静脉压、心率,氨基末端脑钠肽前体、乳酸水平,以及甲肾上腺素用量,治疗前和治疗后2周的左心功能。结果:观察组临床疗效较对照组更为显著(P<0.05)。经治疗两组平均动脉压、收缩压有所升高,观察组较对照组升幅更大;两组中心静脉压、心率均有所降低,观察组较对照组降幅更大(P<0.05)。经治疗两组氨基末端脑钠肽前体、乳酸水平均有所降低,观察组较对照组降幅更大;观察组去甲肾上腺素用量少于对照组(P<0.05)。经治疗两组每搏量、心排血量、心排血指数、左心室射血分数、左心室后壁增厚率及左心室短轴缩短率均有所增加,观察组较对照组增幅更大(P<0.05)。结论:参附注射液联合西药治疗老年急性心肌梗死合并心源性休克疗效确切,可有效改善患者临床症状,调节氨基末端脑钠肽前体与乳酸水平,改善左心功能,利于患者预后。Objective:To investigate the effect of the treatment of acute myocardial infarction with cardiogenic shock on the left ventricular systolic function and prognosis.Methods:According to the random number table method,77 elderly patients with acute myocardial infarction and cardiogenic shock treated in Zhengzhou Municipal Hospital from January 2021 to January 2023 were divided into control group(39 patients)and observation group(38patients).The control group received conventional western medicine therapy,while the observation group included injection based on the treatment of the control group.Both groups were treated for one week.To compare the clinical efficacy of the two groups,mean arterial pressure,systolic pressure,central venous pressure,heart rate,amino terminal minatridium peptide precursor,lactic acid level,and the amount of adrenaline,and left heart function before and 2 weeks after treatment.Results:The clinical effect of the observation group was more significant than that in the control group(P<0.05).The mean arterial pressure and systolic blood pressure increased in the two groups,and the observation group increased more than the control group;the central venous pressure and heart rate decreased in the two groups,and the decrease in the observation group than the control group(P<0.05).The amino-terminal brain natriuretic peptide precursor and lactate levels decreased,and the observation group had less noradrenaline than the control group(P<0.05).After treatment,stroke volume,cardiac output,cardiac output index,left ventricular ejection fraction,left ventricular posterior wall thickening rate and left ventricular short axis shortening rate increased in the two groups,and the observation group increased more than the control group(P<0.05).Conclusion:The treatment of reference injection combined with western medicine in the elderly with acute myocardial infarction combined with cardiogenic shock is effective,which can effectively improve the clinical symptoms of patients,regulate the level of amino termi

关 键 词：急性心肌梗死 心源性休克 参附注射液 

分 类 号：R542.22[医药卫生—心血管疾病]