CD161在免疫相关性疾病中的研究进展  

Research Progress of CD161 in Immune-related Diseases

作　　者：乌丽凡·托勒恒 多力昆·吾甫尔[2] WULIFAN Tuoleheng;DUOLIKUN Wufuer(Graduate School of Xinjiang Medical University,Urumqi 830000,China;Department of Maxillofacial Surgery,Xinjiang Uygur Autonomous Region People′s Hospital,Urumqi 830000,China)

机构地区：[1]新疆医科大学研究生学院,乌鲁木齐830000 [2]新疆维吾尔自治区人民医院颌面外科,乌鲁木齐830000

出　　处：《医学综述》2024年第22期2718-2722,共5页Medical Recapitulate

基　　金：新疆维吾尔自治区自然科学基金(2021D01C158)。

摘　　要：CD161是C型凝集素家族蛋白成员之一,主要参与调节免疫反应,在多种免疫相关性疾病的发生发展过程中发挥重要作用。CD161与其配体凝集素样转录物1结合既可以发挥共刺激作用,又可以发挥抑制作用。表达CD161的T细胞,特别是产生白细胞介素-17的亚群,与银屑病、恶性肿瘤、类风湿关节炎及系统性红斑狼疮等自身免疫性疾病密切相关。免疫相关性疾病的发病机制复杂,明确此类疾病的发病机制成为研究热点,而CD161有望作为免疫相关性疾病诊断和治疗的生物标志物。CD161 is one of the members of the C-lectin family of proteins,which is mainly involved in the regulation of immune responses and plays an important role in the occurrence and development of various immune-related diseases.The binding of CD161 to its ligand lectin-like transcript 1 can play both a costimulatory and an inhibitory role.CD161-expressing T cells,especially subsets producing interleukin-17,have been implicated in autoimmune diseases such as psoriasis,malignancy,rheumatoid arthritis,and systemic lupus erythematosus.Due to the complex pathogenesis of immune-related diseases,the studies of their mechanism have become hot spots,and CD161 is expected to be used as a biomarker for the diagnosis and treatment of immune-related diseases.

关 键 词：免疫相关性疾病 CD161 凝集素样转录物1 调控机制 流式细胞术 

分 类 号：R392.1[医药卫生—免疫学]