基于孟德尔随机化探讨肠道菌群与代谢综合征的关系  

Exploration of Correlation between Gut Microbiota and Metabolic Syndrome Based on Mendelian Randomization

作　　者：王鑫 田润 韩菲 武安琪 王淑君 张慧霞 WANG Xin;TIAN Run;HAN Fei;WU Anqi;WANG Shujun;ZHANG Huixia(The School of Public Health,Guilin Medical University,Guilin 541000,China;Department of Maternal and Child Health,West China School of Public Health/West China Fourth Hospital,Sichuan University,Chengdu 610000,China;Guangxi Key Laboratory of Environmental Exposomics and Entire Lifecycle Health,Guilin 541000,China)

机构地区：[1]桂林医学院公共卫生学院,广西桂林541000 [2]四川大学华西公共卫生学院华西第四医院妇幼保健科,成都610000 [3]广西环境暴露组学与全生命周期健康重点实验室,广西桂林541000

出　　处：《医学综述》2024年第22期2810-2816,共7页Medical Recapitulate

摘　　要：目的基于孟德尔随机化(MR)探讨肠道菌群与代谢综合征(MS)的因果关系。方法从英国基因史研究的全基因组相关研究数据库中提取与肠道菌群和MS相关的单核苷酸多态性(SNP)位点作为干预基因,以工具变量SNP为索引,构建工具变量-暴露因素-结局变量三者的关系。采用MR-Egger、加权中位数、逆方差加权、简单模式和加权模式5种MR分析方法,探究肠道菌群与MS的因果关系。结果逆方差加权结果显示,拟杆菌目-S24-7、双歧杆菌科、粪球菌属1、双歧杆菌目和放线菌门是MS的保护因素(OR=0.936,95%CI 0.882~0.992,P=0.026;OR=0.928,95%CI 0.868~0.992,P=0.028;OR=0.922,95%CI 0.860~0.988,P=0.021;OR=0.928,95%CI 0.868~0.992,P=0.028;OR=0.935,95%CI 0.878~0.996,P=0.037),韦荣球菌科、奥尔森菌属和厚壁菌门是MS的危险因素(OR=1.055,95%CI 1.004~1.108,P=0.034;OR=1.046,95%CI 1.009~1.085,P=0.015;OR=1.063,95%CI 1.006~1.124,P=0.031)。另外4种方法与逆方差加权的方向一致。结论厚壁菌门、放线菌门、双歧杆菌目、拟杆菌目-S24-7、双歧杆菌科、韦荣球菌科、粪球菌属1和奥尔森菌属与MS之间存在因果关联。Objective To explore the causal correlation between gut microbiota and metabolic syndrome(MS)based on Mendelian randomization(MR).Methods The single nucleotide polymorphisms(SNP)loci related to gut microbiota and MS were extracted from the genome wide related study database of genetic history research in the UK as intervention genes.The instrumental variable SNP was used as an index to construct the relationship between instrumental variable-exposure factor-outcome variable.Five MR analysis methods,including MR-Egger,weighted median,inverse variance weighted,simple mode and weighted mode,are used to explore the causal relationship between gut microbiota and MS.Results The inverse variance weighted analysis results showed that Bacteroidales S24-7 group,Bifidobacteriaceae,Coprococcus 1,Bifidobacteriales and Actinobacteria were protective factors for MS(OR=0.936,95%CI 0.882-0.992,P=0.026;OR=0.928,95%CI 0.868-0.992,P=0.028;OR=0.922,95%CI 0.860-0.988,P=0.021;OR=0.928,95%CI 0.868-0.992,P=0.028;OR=0.935,95%CI 0.878-0.996,P=0.037),Veillonellaceae,Olsenella and Firmicutes were risk factors for MS(OR=1.055,95%CI 1.004-1.108,P=0.034;OR=1.046,95%CI 1.009-1.085,P=0.015;OR=1.063,95%CI 1.006-1.124,P=0.031).The other four methods agreed with the direction of the inverse variance weighting.Conclusion There are causal associations of gut microbiota Firmicutes,Actinobacteria,Bifidobacteriales,Bacteroidales S24-7 group,Bifidobacteriaceae,Veillonellaceae,Coprococcus 1 and Olsenella with MS.

关 键 词：代谢综合征 肠道菌群 孟德尔随机化研究 

分 类 号：R721[医药卫生—儿科]