Research advances in the function and anti-aging effects of nicotinamide mononucleotide  

作　　者：Min WANG Yuan CAO Yun LI Lu WANG Yuyan LIU Zihui DENG Lianrong ZHU Hongjun KANG 

机构地区：[1]Chinese PLA Medical School,Beijing,100853,China [2]Department of Critical Care Medicine,the First Medical Centre,Chinese PLA General Hospital,Beijing,100853,China [3]Department of Emergency,The Second Hospital of Hebei Medical University,Shijiazhuang,050004,China [4]Department of Biochemistry,Chinese PLA Medical School,Beijing,100853,China [5]Department of Clinical Nutrition,the First Medical Centre,Chinese PLA General Hospital,Beijing,100853,China [6]Nephrology Institute of the Chinese People’s Liberation Army,State Key Laboratory of Kidney Diseases,National Clinical Research Center for Kidney Diseases,Beijing Key Laboratory of Kidney Disease Research,Department of Nephrology,the First Medical Center,Chinese PLA General Hospital,Beijing,100853,China

出　　处：《Journal of Zhejiang University-Science B(Biomedicine & Biotechnology)》2024年第9期723-735,共13页浙江大学学报（英文版）B辑（生物医学与生物技术）

摘　　要：Aging and age-related ailments have emerged as critical challenges and great burdens within the global contemporary society.Addressing these concerns is an imperative task,with the aims of postponing the aging process and finding effective treatments for age-related degenerative diseases.Recent investigations have highlighted the significant roles of nicotinamide adenine dinucleotide(NAD+)in the realm of anti-aging.It has been empirically evidenced that supplementation with nicotinamide mononucleotide(NMN)can elevate NAD+levels in the body,thereby ameliorating certain age-related degenerative diseases.The principal anti-aging mechanisms of NMN essentially lie in its impact on cellular energy metabolism,inhibition of cell apoptosis,modulation of immune function,and preservation of genomic stability,which collectively contribute to the deferral of the aging process.This paper critically reviews and evaluates existing research on the anti-aging mechanisms of NMN,elucidates the inherent limitations of current research,and proposes novel avenues for anti-aging investigations.

关 键 词：Nicotinamide mononucleotide(NMN) ANTI-AGING Energy metabolism APOPTOSIS DNA repair 

分 类 号：R339.38[医药卫生—人体生理学]