复方消炎膏促进肛瘘术后创面愈合的临床疗效观察  

Clinical Observation of Compound Anti-inflammatory Ointment and its Application on Wound Management after Anal Fistula Operation

作　　者：武永连 武晗 张胜男 王方见 丁康[2] WU Yonglian;WU Han;ZHANG Shengnan;WANG Fangjian;DING Kang(Department of Anorectal Disease,Yingshang Hospital of Traditional Chinese Medicine,Fuyang 236200,China;Department of Anorectal Disease,Nanjing Hospital of Traditional Chinese Medicine Afiliated to Nanjing University of Traditional Chinese Medicine,Nanjing 210022,China;School of Pharmacy,China Pharmaceutical University,Nanjing 210000,China)

机构地区：[1]安徽省阜阳市颍上县中医院肛肠科,安徽阜阳236200 [2]南京中医药大学附属南京中医院肛肠科,江苏南京210022 [3]中国药科大学药学院,江苏南京210000

出　　处：《现代中药研究与实践》2024年第4期83-86,共4页Research and Practice on Chinese Medicines

基　　金：安徽省中医药传承创新科研项目(2022CCZD10);阜阳市卫健委中医项目(卫科教函[2021]260号);镇江市脾胃病临床医学研究中心开放课题项目(SSPW2022-KF04);南京大学中国医院改革发展研究院2023年全国范围内拟立项课题(NDYG029,NDYG025);江苏省医院协会2023年度医院管理创新课题(JSYGY-3-2023-515,JSYGY-2-2023-507);江苏省中医药科技发展计划项目(MS2022134)。

摘　　要：目的观察复方消炎膏对肛瘘术后创面愈合的临床效果。方法将2021年2月至2022年2月61例接受高位复杂肛瘘切开挂线术患者随机分为两组,治疗组(n=30)创面外用复方消炎膏换药,对照组(n=31)创面外用凡士林纱布换药,两组均在术后第2天开始换药。观察两组术后第2、7天创面分泌物、切缘水肿、创面疼痛评分及炎症因子变化。结果术后2 d两组创面分泌物评分均明显升高,但两组间对比差异无统计学意义(P>0.05)。而术后7 d,治疗组经过药物处理创面分泌物比对照组改善更明显(P<0.05)。创缘水肿程度评分结果提示术后2 d,两组均创缘多处水肿,评分对比差异无统计学意义(P>0.05)。术后7 d,两组创缘多处水肿范围缩小,但两组评分对比差异无统计学意义(P>0.05)。两组VAS评分对比术后2 d差异无统计学意义(P>0.05),而术后7 d,治疗组疼痛改善程度优于对照组(P<0.05)。两组渗出量比较结果提示术后2 d治疗组组渗出量为(27.43±12.04)mL,对照组(32.74±9.87)mL,两组对比差异无统计学意义(P>0.05),术后7 d治疗组(14.10±5.22)mL,对照组(19.74±7.89)mL,治疗组渗出量少于对照组(P<0.05)。治疗后复方消炎膏对炎症因子IL-6、TNF-α、IL-1均有明显的改善作用(P<0.05)。结论复方消炎膏应用于肛瘘术后换药,在减轻患者创面渗液、水肿、疼痛症状及抑制炎症因子方面临床疗效明显。Objectivee To assess the clinical efficacy of a compound anti-inflammatory ointment on wound healing post-anal fistula surgery.Methods From February 2021 to February 2022,61 patients undergoing high-level complex anal fistula incision and drainage surgery were randomized into two groups.The treatment group(n=30)received topical application of the compound anti-inflammatory ointment,while the control group(n=31)used Vaseline gauze.Dressing changes commenced on the second day post-surgery.Evaluations included wound secretion,perianal edema,wound pain scores,and inflammatory markers on the 2nd and 7th days postsurgery.Results On the 2nd day post-surgery,both groups exhibited increased wound secretion scores;however,no statistically significant differences were observed(P>0.05).By the 7th day,the treatment group showed more significant improvement in wound secretion compared to the control group(P<0.05).Initial assessments of perianal edema on the 2nd day showed extensive edema in both groups,with no significant differences in edema scores(P≥>0.05).By the 7th day,the extent of edema had decreased in both groups,yet without significant differences between them(P>0.05).Pain levels,assessed via the Visual Analog Scale(VAS),did not differ significantly between the groups on the 2nd day(P>0.05).However,on the 7th day,pain improvement was notably better in the treatment group(P<0.05).The comparison of exudate volumes between the two groups revealed that on the 2nd day post-surgery,the treatment group recorded an exudate volume of(27.43±12.04)mL,compared to(32.74±9.87)mL in the control group.This difference was not statistically significant(P>0.05).However,on the 7th day post-surgery,the exudate volume in the treatment group was significantly reduced to(14.10±5.22)mL,whereas the control group exhibited a volume of(19.74±7.89)mL(P<0.05).This indicates a statistically significant decrease in the treatment group compared to the control group.Additionally,the application of the compound anti-inflammatory ointment demonstr

关 键 词：肛瘘 复方消炎膏 创面愈合 

分 类 号：R285.6[医药卫生—中药学]