上转换荧光纳米材料Gd_(2)O_(3):Yb,Tm,Zn在光动力抗菌疗法中的应用  

Applications of Up-conversion Fluorescent Nanomaterials Gd_(2)O_(3):Yb,Tm,Zn in Photodynamic Antibacterial Therapy

作　　者：王晨曦 王玮[1] WANG Chenxi;WANG Wei(College of Materials Science and Engineering,Qingdao University of Science and Technology,Qingdao 266042,China)

机构地区：[1]青岛科技大学材料科学与工程学院,山东青岛266042

出　　处：《青岛科技大学学报（自然科学版）》2024年第5期84-91,100,共9页Journal of Qingdao University of Science and Technology:Natural Science Edition

基　　金：山东省自然科学基金项目(ZR2022ME124)。

摘　　要：采用简单水热法合成了上转换荧光纳米材料Gd_(2)O_(3):Yb,Tm,Zn,在980 nm激光照射下所发出的蓝色荧光能够被光敏剂部花青540(MC540)吸收,并激活其光敏反应,产生单线态氧。利用该原理,实现了由Gd_(2)O_(3):Yb,Tm,Zn介导的近红外光响应的光动力抗菌疗法,对耐药细菌大肠杆菌以及金黄色葡萄球菌的体外杀伤率分别高达92%以及88%。Gd_(2)O_(3):Yb,Tm,Zn nanoparticles were synthesized by a simple hydrothermal method.The blue fluorescence produced under 980 nm near infrared(NIR)laser irradiation was absorbed by the photosensitizer merocyanine 540(MC540),which activated the photo-sensitive reaction to produce singlet oxygen.By using this principle,antibacterial photody-namic therapy mediated by Gd_(2)O_(3):Yb,Tm,Zn was achieved,and the killing rate against drug-resistant bacteria E.coli and S.aureus reached 92%and 88%in vitro,respectively.

关 键 词：光动力治疗 抗菌 上转换荧光 近红外响应 

分 类 号：TB34[一般工业技术—材料科学与工程]