血小板/淋巴细胞比值对晚期结肠癌化疗患者1年内死亡的预测价值  

Predictive value of LPR for one-year death in patients with advanced colon cancer undergoing chemotherapy

作　　者：戴运刚[1] 路明[2] DAI Yungang;LU Ming(Department of Anorectal Surgery,Jilin City Central Hospital,Jilin 132011,Jilin,China;The Second Department of Gastrointestinal Surgery,Jilin City Central Hospital,Jilin 132011,Jilin,China)

机构地区：[1]吉林市中心医院肛肠外科,吉林吉林132011 [2]吉林市中心医院胃肠外科二科,吉林吉林132011

出　　处：《中国现代医生》2024年第29期28-32,共5页China Modern Doctor

基　　金：吉林省吉林市医疗卫生指导性项目(20230406213)。

摘　　要：目的探讨血小板/淋巴细胞比值(platelet to lymphocyte ratio,PLR)对晚期结肠癌化疗患者1年内死亡的预测价值。方法选取2021年3月至2023年3月在吉林市中心医院确诊的晚期结肠癌且接受化疗患者166例,随访1年,发生死亡72例为死亡组,存活94例为生存组。对比两组患者的临床病理学资料及PLR、癌胚抗原(carcinoembryonic antigen,CEA)、糖类抗原(carbohydrate antigen,CA)199、CA724及CA153水平。晚期结肠癌患者1年内发生死亡的影响因素采用多因素Logistic回归分析,受试者操作特征(receiver operating characteristic,ROC)曲线评价PLR对晚期结肠癌患者1年内发生死亡的预测价值。结果入组患者1年内死亡率为43.37%。与生存组比较,死亡组患者的性别、年龄、肿瘤淋巴结转移分类(tumor node metastasis classification,TNM)分期、所在结肠部位、化疗疗程数、癌症史差异无统计学意义(P>0.05),糖尿病史、吸烟史、PLR、CEA、CA199、CA724、CA153水平差异有统计学意义(P<0.05)。多因素Logistic回归分析结果显示,PLR(OR=1.056,95%CI:1.000~1.116)、CEA(OR=20.122,95%CI:2.602~155.617)、CA199(OR=1.227,95%CI:1.069~1.408)、CA724(OR=1.864,95%CI:1.174~2.962)及CA153(OR=1.741,95%CI:1.108~2.737)水平是晚期结肠癌化疗患者1年内死亡的危险因素(P<0.05)。ROC曲线结果表明,PLR水平预测晚期结肠癌化疗患者1年内死亡的曲线下面积为0.79,敏感度及特异性分别为52.78%和95.74%。结论晚期结肠癌化疗1年内死亡患者,PLR水平明显高于生存患者,PLR水平在评估晚期结肠癌化疗1年内死亡时有一定的参考价值。Objective To investigate the value of platelet/lymphocyte ratio(PLR)in predicting death within 1 year in patients with advanced colon cancer undergoing chemotherapy.Methods A total of 166 patients diagnosed with advanced colon cancer were selected from March 2021 to March 2023 in Jilin City Central Hospital.During 1-year follow-up,72 patients died(death group)and 94 survived(survival group).The clinicopathological data and the levels of PLR,carcinoembryonic antigen(CEA),carbohydrate antigen(CA)199,CA724 and CA153 were compared between two groups.The influencing factors of death within 1 year in patients with advanced colon cancer were analyzed by multivariate Logistic regression.Receiver operating characteristic(ROC)curve evaluated the predictive value of PLR for death within 1 year in patients with advanced colon cancer.Results The mortality rate within 1 year was 43.37%.Compared with survival group,there was no statistically significant difference in gender,age,tumor node metastasis classification stage,location of colon,number of chemotherapy courses,and cancer history in death group(P>0.05),but there were differences in diabetes history,smoking history,PLR,CEA,CA199,CA724 and CA153 levels in death group(P<0.05).Multivariate Logistic regression analysis showed that PLR(OR=1.056,95%CI:1.000-1.116),CEA(OR=20.122,95%CI:2.602-155.617),CA199(OR=1.227,95%CI:1.069-1.408),CA724(OR=1.864,95%CI:1.174-2.962)and CA153(OR=1.741,95%CI:1.108-2.737)levels were risk factors for death within 1 year in patients with advanced colon cancer undergoing chemotherapy(P<0.05).The ROC curve showed that the area under the curve of PLR level predicting death within 1 year in patients with advanced colon cancer chemotherapy was 0.79,and the sensitivity and specificity were 52.78%and 95.74%,respectively.Conclusion The level of PLR in patients who died within 1 year of chemotherapy for advanced colon cancer was significantly higher than that in patients who survived.PLR levels have reference value in assessing death within 1 year of chemothe

关 键 词：血小板/淋巴细胞比值 晚期结肠癌 死亡率 

分 类 号：R753.3[医药卫生—皮肤病学与性病学]