玉液汤联合二甲双胍治疗2型糖尿病的Meta分析  

Efficacy and safety of Yuye decoction combination with metformin in type 2 diabetes mellitus:A Meta-analysis

作　　者：陈家祈 王丽 朴春丽 CHAN Kakei;WANG Li;PIAO Chunli(Department of Endocrinology,Shenzhen Hospital(Futian)of Guangzhou University of Chinese Medicine,Shenzhen 518000,Guangdong,China)

机构地区：[1]广州中医药大学深圳医院(福田)内分泌科,广东深圳518000

出　　处：《中国现代医生》2024年第29期77-81,94,共6页China Modern Doctor

基　　金：广东省深圳市福田区卫生健康系统科研项目(FTWS2022036)。

摘　　要：目的旨在通过Meta分析系统评价玉液汤联合二甲双胍治疗2型糖尿病(type 2 diabetes mellitus,T2DM)的有效性与安全性。方法通过检索中国知网、万方知识服务平台、维普网、中国生物医学文献数据库、PubMed、EMbase、Cochrane Library、Web of Science 8个中英文数据库,收集10篇研究内容为玉液汤联合二甲双胍治疗T2DM随机对照试验的文献进行Meta分析,对文献进行质量评价,对糖化血红蛋白(glycated hemoglobin A1c,HbA1c)、胰岛素抵抗指数(homeostatic model assessment for insulin resistance,HOMA-IR)、总胆固醇(total cholesterol,TC)、临床有效率及不良反应率等观察指标进行分析。结果试验组右HbA1c、HOMA-IR、TC及临床有效率改善方面均优于对照组,差异有统计学意义(P<0.05)。在不良反应发生率方面,两组比较差异无统计学意义(P>0.05)。结论玉液汤联合二甲双胍可改善糖脂代谢、胰岛素抵抗,延缓糖尿病的发展,目前尚未发现严重不良反应。Objective To access the efficacy and safety of Yuye decoction combination with metformin in the treatment of type 2 diabetes mellitus(T2DM).Methods A total of 8 databases including CNKI,Wanfang,VIP,SinoMed,PubMed,EMbase Cochrane Library,and Web of Science were retrieved for randomized controlled trial(RCT)of Yuye decoction in the treatment of T2DM.A total of 10 RCTs were included in the final Meta-analysis.The primary outcome was glycated hemoglobin A1c(HbA1c).Secondary outcomes include homeostatic model assessment for insulin resistance(HOMA-IR),total cholesterol(TC),clinical effective rate and adverse event rate.Results The Meta-analysis revealed that the improvements of HbA1c,HOMA-IR,TC and clinical effective rate in experimental group were better than those in control group(P<0.05).There was no serious adverse effects being observed in both experimental group and control group.Conclusion The combination of Yuye decoction and metformin could improve blood glucose and lipid profile as well as reduce insulin resistance,and no serious adverse reactions were observed.

关 键 词：玉液汤 2型糖尿病 临床研究 系统评价 META分析 

分 类 号：R587.1[医药卫生—内分泌]