基于多糖及熵权-TOPSIS的灵芝孢子粉药材质量评价  

Quality Evaluation of Ganodermalucidum Spore Powder Based on Polysaccharide and Entropy Weight-TOPSIS

作　　者：杨志城 孙彩虹 叶冠 YANG Zhicheng;SUN Caihong;YE Guan(Institute of Traditional Chinese Medicine,Shanghai Pharmaceutical Group Co.,Ltd,Shanghai 201203,China)

机构地区：[1]上海医药集团股份有限公司中药研究所,上海201203

出　　处：《中医药导报》2024年第10期65-70,共6页Guiding Journal of Traditional Chinese Medicine and Pharmacy

基　　金：上海医药中药传承和创新平台能力建设项目(2020006)。

摘　　要：目的:基于多糖部位及熵权-逼近理想解排序法(TOPSIS)模型建立灵芝孢子粉药材综合定量评价模型,为灵芝孢子粉药材质量评价及优选最佳批次提供参考。方法:测定同产地不同批次灵芝孢子粉药材粗多糖的得率、糖组成、总糖含量、蛋白含量和糖醛酸含量,将数据进行无量纲化后采用熵权-TOPSIS法综合评价不同批次灵芝孢子粉质量并建立优选标准。结果:各批次灵芝孢子粉外观均符合2020年版《中华人民共和国药典》描述。多糖质控指标中,熵权法赋权结果显示提取得率占比权重系数最大为28.44%,其次为半乳糖含量18.82%、总糖含量13.84%、蛋白含量13.24%。TOPSIS排序结果及分组显示,当相对贴近度(C_(i))≥0.55时,灵芝孢子粉为优质药材;当0.45≤C_(i)<0.55时,灵芝孢子粉为中等品质药材;当C_(i)<0.45时,灵芝孢子粉为下等品质药材。结论:不同批次间灵芝孢子粉质量差异较大。基于多指标的熵权-TOPSIS法可实现对灵芝孢子粉药材快速、高效且准确地优选优质药材来源,在生产和质量全面评价中有广泛的应用前景,也可为其他中药材或饮片质量评价提供参考。Objective:To establish a comprehensive quantitative evaluation model of Ganodermalucidum spore powder medicinal materials based on the polysaccharide parts and entropy weight-approximating ideal solution ranking method(TOPSIS)model to provide a reference for the quality evaluation of Ganodermalucidum spore powder medicinal materials and the selection of the best batch.Method:The crude polysaccharide yield,sugar composition,total sugar content,protein content and uronic acid content of different batches of Ganodermalucidum spore powder from the same origin were determined.The data were dimensionless and then the entropy weight-TOPSIS method was used to comprehensively evaluate the different batches.The quality of Ganodermalucidum spore powder was determined and the optimization standard was established.Results:The appearance of each batch of Ganodermalucidum spore powder conformed to the description in Chinese Pharmacopoeia 2020 Edition.Among the polysaccharide quality control indicators,the weighting result of the entropy weight method showed that the maximum extraction rate weight coefficient was 28.44%,followed by galactose content of 18.82%,total sugar content of 13.84%,and protein content of 13.24%.The TOPSIS ranking results and grouping showed that when the relative proximity C_(i)≥0.55,Ganodermalucidum spore powder was a high-quality medicinal material;when the relative proximity was 0.45≤C_(i)<0.55,Ganodermalucidum spore powder was a medium medicinal material;when the relative proximity C_(i)<0.45,Ganodermalucidum spore powder was a low-quality medicinal material.Conclusion:There was a significant difference in the quality of Ganodermalucidum spore powder between different batches.The entropy weight-TOPSIS method based on multiple indicators can achieve rapid,efficient,and accurate selection of high-quality medicinal materials for Ganodermalucidum spore powder.It has broad application prospects in production and comprehensive quality evaluation,and can also provide reference for the quality evaluation

关 键 词：灵芝孢子粉 熵权-逼近理想解排序法 质量评价 多糖 糖组成 糖醛酸 

分 类 号：R284.1[医药卫生—中药学]