盐酸坦索罗辛缓释胶囊对输尿管体外冲击波碎石术后患者预后的影响  

Effect of tamsulosin hydrochloride sustained-release capsules on the prognosis of patients after ureteral extracorporeal shockwave lithotriptic surgery

作　　者：张冲 唐飞[1] 朱文尧 ZHANG Chong;TANG Fei;ZHU Wen-yao(Department of Urology,Bengbu Third People's Hospital,Bengbu 233099,China)

机构地区：[1]蚌埠市第三人民医院泌尿外科,安徽蚌埠233099

出　　处：《中国处方药》2024年第10期137-141,共5页Journal of China Prescription Drug

摘　　要：目的探究盐酸坦索罗辛缓释胶囊对输尿管体外冲击波碎石术后患者预后的影响。方法按照随机数字表法将某院2022年6月~2023年5月期间纳入的输尿管体外冲击波碎石术后患者60例分为对照组(呋塞米治疗,n=30)和研究组(呋塞米片+盐酸坦索罗辛缓释胶囊联合治疗,n=30)。比较两组结石排出状况、肾功能、炎症反应、生活质量、不良事件发生情况等指标的变化差异,评估两组临床疗效。结果相较于对照组(73.33%),研究组临床总有效率(96.67%)更高,差异有统计学意义(P<0.05);研究组结石排出状况各指标均优于对照组(P<0.05);治疗3周后研究组肾功能、炎症反应、生活质量各指标水平均优于对照组(P<0.05);相较于对照组(26.67%),研究组不良事件发生率(6.67%)更低(P<0.05)。结论盐酸坦索罗辛缓释胶囊治疗输尿管体外冲击波碎石术后患者,其结石排出状况、肾功能、炎症反应、生活质量均得到改善,不良事件发生风险低,疗效显著。Objective To explore the effect of tamsulosin hydrochloride sustained-release capsules on the prognosis of patients after ureteral extracorporeal shockwave lithotriptic surgery.Methods According to the random number table method,60 patients with ureteral extracorporeal shockwave lithotriptic surgery enrolled in a hospital from June 2022 to May 2023 were divided into the control group(furosemide treatment,n=30)and the study group(furosemide tablets+tamsulosin hydrochloride sustained-release capsules combined therapy,n=30).The change difference in the indicators of stone discharge status,renal function,inflammatory response,quality of life,adverse events between the two groups were compared,and the clinical efficacy of the two groups were evaluated.Results Compared with the control group(73.33%),the total clinical effective rate of the study group(96.67%)was higher(P<0.05).The indexes of stone discharge status in the study group were better than those in the control group(P<0.05).After 3 weeks of treatment,renal function,inflammation and quality of life in the study group were better than those in the control group(P<0.05).Compared with the control group(26.67%),the incidence of adverse events in the study group(6.67%)was lower(P<0.05).Conclusion Using tamsulosin hydrochloride sustained release capsules in patients after ureteral extracorporeal shockwave lithotripsy can improve stone discharge status,renal function,inflammatory response and quality of life,with low risk of adverse events and significant curative effect.

关 键 词：盐酸坦索罗辛缓释胶囊 输尿管结石 体外冲击波碎石 肾功能 炎症反应 生活质量 不良事件发生情况 

分 类 号：R699.4[医药卫生—泌尿科学]