情绪刺激下恐惧反应的神经机制:结合早期后部负波和脑电图源网络分析的初步研究  

Neural mechanisms of fear responses to emotional stimuli:a preliminary study combining early posterior negativity and electroencephalogram source network analysis

作　　者：臧倩[1,2] 赵小茗 梁铁[2,3,4] 刘秀玲 娄存广[2,3] ZANG Qian;ZHAO Xiaoming;LIANG Tie;LIU Xiuling;LOU Cunguang(Center for Student Mental Health and Development,Hebei University,Baoding,Hebei 071002,P.R.China;Key Laboratory of Digital Medical Engineering of Hebei Province,Hebei University,Baoding,Hebei 071002,P.R.China;College of Electronic and Information Engineering,Hebei University,Baoding,Hebei 071002,P.R.China;Guangxi Health Commission Key Laboratory of Basic Research on Brain Function and Disease,Guangxi Medical University,Nanning 530021,P.R.China)

机构地区：[1]河北大学学生心理健康与发展中心,河北保定071002 [2]河北大学数字医疗工程重点实验室,河北保定071002 [3]河北大学电子信息工程学院,河北保定071002 [4]广西医科大学广西脑功能与脑疾病基础研究重点实验室,南宁530021

出　　处：《生物医学工程学杂志》2024年第5期951-957,共7页Journal of Biomedical Engineering

基　　金：国家重点研发计划基金资助项目(2017YFB1401200);河北省自然科学基金资助项目(F2021201002);河北省高等学校科学技术研究项目(ZD2020146);广西脑功能与脑疾病基础研究实验室(GXBD202403)。

摘　　要：作为典型的负性情绪,恐惧情绪普遍存在于日常生活中并显著影响人类行为。深入了解负性情绪的产生机制有助于提高相关疾病的诊疗效果。然而大脑面对恐惧情绪刺激时的神经机制依旧不明。为此,本研究在早期后部负波(EPN)分析基础上,进一步将脑电图(EEG)源分析和皮层脑网络构建相结合,从时-空角度探索了恐惧和中性情绪图片刺激下大脑信息处理机制的差异。结果发现中性情绪刺激能够比恐惧刺激诱发更高幅值的EPN。进一步通过对包含EPN成分的EEG数据执行溯源分析发现,恐惧和中性情绪刺激下的大脑皮层激活区域存在明显差异。此外,在alpha频段脑网络观察到恐惧情绪相比中性情绪存在更多的功能连接。通过量化脑网络属性发现,与中性情绪相比,恐惧情绪刺激下的平均节点度和平均聚类系数明显更大。结果表明,将ERP、EEG溯源以及脑网络分析相结合,有助于以较高的时-空分辨率探究恐惧情绪处理进程中的脑功能调制,也为探索负性情绪的神经机制提供了新的视角。Fear emotion is a typical negative emotion that is commonly present in daily life and significantly influences human behavior.A deeper understanding of the mechanisms underlying negative emotions contributes to the improvement of diagnosing and treating disorders related to negative emotions.However,the neural mechanisms of the brain when faced with fearful emotional stimuli remain unclear.To this end,this study further combined electroencephalogram(EEG)source analysis and cortical brain network construction based on early posterior negativity(EPN)analysis to explore the differences in brain information processing mechanisms under fearful and neutral emotional picture stimuli from a spatiotemporal perspective.The results revealed that neutral emotional stimuli could elicit higher EPN amplitudes compared to fearful stimuli.Further source analysis of EEG data containing EPN components revealed significant differences in brain cortical activation areas between fearful and neutral emotional stimuli.Subsequently,more functional connections were observed in the brain network in the alpha frequency band for fearful emotions compared to neutral emotions.By quantifying brain network properties,we found that the average node degree and average clustering coefficient under fearful emotional stimuli were significantly larger compared to neutral emotions.These results indicate that combining EPN analysis with EEG source component and brain network analysis helps to explore brain functional modulation in the processing of fearful emotions with higher spatiotemporal resolution,providing a new perspective on the neural mechanisms of negative emotions.

关 键 词：恐惧 早期后部负波 脑电溯源分析 负性情绪 

分 类 号：R338[医药卫生—人体生理学]