非均匀泊松比防移位气管支架的结构设计及力学分析的数值研究  

Numerical study on structural design and mechanical analysis of anti-migration tracheal stent with non-uniform Poisson’s ratio

作　　者：陶克怡 孙浩[1,2] 刘昭 杜田明 张艳萍 程渊[3] 黄俊芳 乔爱科[1,2] TAO Keyi;SUN Hao;LIU Zhao;DU Tianming;ZHANG Yanping;CHENG yuan;HUANG JunfangQIAO Aike(Department of Biomedical Engineering,College of Chemistry and Life Sciences,Beijing University of Technology,Beijing 100124,P.R.China;Intelligent Physiological Measurement and Clinical Translation,Beijing International Base for Scientific and Technological Cooperation,Beijing 100124,P.R.China;Department of Respiratory and Critical Care medicine,Peking University First Hospital,Beijing 100034,P.R.China)

机构地区：[1]北京工业大学化学与生命科学学院生物医学工程系,北京100124 [2]智能化生理测量与临床转化北京市国际科研合作基地,北京100124 [3]北京大学第一医院呼吸和危重症医学科,北京100034

出　　处：《生物医学工程学杂志》2024年第5期1035-1045,共11页Journal of Biomedical Engineering

基　　金：国家自然科学基金项目(12172018)。

摘　　要：支架移位是气管支架植入后的常见并发症之一,其原因包括支架与气管之间尺寸不匹配、气管的生理运动等。针对以上问题,本研究在保证支架支撑性的同时,结合气管尺寸结构与气管的生理运动,设计非均匀泊松比气管支架以改善支架的移位问题。本研究在对应软骨部分的支架采用负泊松比结构,对应环间结缔组织及后膜部分的支架采用正泊松比结构,并设计了连杆长度不同、负泊松比不同的4种非均匀泊松比气管支架。然后,本文以数值模拟支架植入后的扩张回弹过程,观察支架的支撑性,进一步模拟气管拉伸运动,计算不同的负泊松比结构对应支架部分的直径变化;并利用在气管壁施加不同呼吸压,记录支架的轴向位移以评价支架是否具有防移位效果。研究结果显示,连杆长度为3 mm的非均匀泊松比支架在气管拉伸时,其负泊松比部分直径扩张最大;和正泊松比结构支架相比,剧烈呼吸时的轴向位移从0.024 mm减少到0.012 mm。本研究所设计的非均匀泊松比支架的负泊松比结构在气管内拉胀效应未失效,与传统支架相比,在保证支架支撑力的同时,非均匀泊松比气管支架在气管正常运动下具有防移位效果。Stent migration is one of the common complications after tracheal stent implantation.The causes of stent migration include size mismatch between the stent and the trachea,physiological movement of the trachea,and so on.In order to solve the above problems,this study designed a non-uniform Poisson ratio tracheal stent by combining the size and structure of the trachea and the physiological movement of the trachea to improve the migration of the stent,meanwhile ensuring the support of the stent.In this study,the stent corresponding to cartilage was constructed with negative Poisson's ratio,and the stent corresponding to the circular connective tissue and muscular membrane was constructed with positive Poisson's ratio.And four kinds of non-uniform Poisson's ratio tracheal stents with different link lengths and negative Poisson's ratio were designed.Then,this paper numerically simulated the expansion and rebound process of the stent after implantation to observe the support of the stent,and further simulated the stretch movement of the trachea to calculate the diameter changes of the stent corresponding to different negative Poisson's ratio structures.The axial migration of the stent was recorded by applying different respiratory pressure to the wall of the tracheal wall to evaluate whether the stent has anti-migration effect.The research results show that the non-uniform Poisson ratio stent with connecting rod length of 3 mm has the largest diameter expansion in the negative Poisson ratio section when the trachea was stretched.Compared with the positive Poisson's ratio structure,the axial migration during vigorous breathing was reduced from 0.024 mm to 0.012 mm.The negative Poisson's ratio structure of the non-uniform Poisson's ratio stent designed in this study did not fail in the tracheal expansion effect.Compared with the traditional stent,the non-uniform Poisson's ratio tracheal stent has an anti-migration effect under the normal movement of the trachea while ensuring the support force of the stent.

关 键 词：气管支架 支架移位 负泊松比 数值模拟 生物力学 

分 类 号：TH77[机械工程—仪器科学与技术]