外用重组人酸性成纤维细胞生长因子促进肛瘘(单纯性低位肛瘘)术后创面愈合的临床疗效观察  

Clinical observation of external application of recombinant human acidic fibroblast growth factor in promoting wound healing after anal fistula(simple low anal fistula)operation

作　　者：李理 范海娜 王清桃 皮茂 LI Li;FAN Haina;WANG Qingtao;PI Mao

机构地区：[1]湘潭市中医医院,湖南湘潭411100

出　　处：《中医临床研究》2024年第18期107-109,共3页Clinical Journal Of Chinese Medicine

摘　　要：目的:肛瘘为肛肠科常见病,虽然医疗技术的发展已经大大提高了肛瘘的治疗效率,但肛瘘术后漫长且痛苦的康复过程给患者的生活及工作均带来了不同程度的影响。本研究目的在于观察外用重组人酸性成纤维细胞生长因子促进单纯性低位肛瘘术后创面愈合的临床疗效。方法:将60例肛瘘(单纯性低位肛瘘)术后患者随机分为治疗组30例和对照组30例。治疗组及对照组术后前6天均使用甲硝唑氯化钠注射液纱条给肛瘘创面换药;治疗组术后第7天开始使用外用重组人酸性成纤维细胞生长因子纱条给肛瘘创面换药,对照组第7天开始使用0.9%氯化钠注射液纱条给肛瘘创面换药。观察术后第6天、第14天、第21天两组病例术后创面疼痛程度、分泌物等情况以及创面愈合时间。结果:用药后第14天、第21天两组创面疼痛、分泌物积分方面均有统计学意义(P<0.05)。治疗组愈合时间最短19 d,最长26 d,平均(22.40±1.55)d。对照组愈合时间最短24 d,最长29 d,平均(26.13±1.50)d;两组创面平均愈合时间比较差异有统计学意义(P<0.05)。结论:使用外用重组人酸性成纤维细胞生长因子纱条给肛瘘术后创面换药,能有效缓解术后创面疼痛,减少创面分泌物,促进创面愈合。外用重组人酸性成纤维细胞生长因子对肛瘘术后创面有良好的治疗作用,疗效优于0.9%氯化钠注射液纱条换药组,是一种安全有效治疗方式。Objective:Anal fistula is a common disease in the field of proctology.Although the development of medical technology has greatly improved the treatment efficiency of anal fistula,the long and painful recovery process after anal fistula surgery has had varying degrees of impact on the patient's life and work.The purpose of this study is to observe the clinical efficacy of exogenous recombinant human acidic fibroblast growth factor in promoting wound healing after simple low anal fistula surgery.Method:Sixty postoperative patients with anal fistula(simple low anal fistula)were randomly divided into a treatment group of 30 cases and a control group of 30 cases.Both the treatment group and the control group were treated with metronidazole and sodium chloride injection gauze strips for dressing changes on the anal fistula wound for the first 6 days after surgery.On the 7th day after surgery,the treatment group began to use externally applied recombinant human acidic fibroblast growth factor gauze to change dressing on the anal fistula wound.On the 7th day,the control group began to use 0.9%sodium chloride injection gauze to change dressing on the anal fistula wound.Observe the degree of postoperative wound pain,secretions,and wound healing time in two groups of patients on the 6th,14th,and 21st day after surgery.Results:On the 14th and 21st day after medication,both groups showed statistical significance in terms of wound pain and secretion score(P<0.05).The shortest healing time in the treatment group was 19 days,and the longest was 26 days,with an average of(22.40±1.55)days.The healing time of the control group was the shortest 24 days and the longest 29 days,with an average of(26.13±1.50)days;The average healing time of the two groups of wounds was statistically significant(P<0.05).Conclusion:The use of externally applied recombinant human acidic fibroblast growth factor gauze strips to change dressing on the wound after anal fistula surgery can effectively alleviate postoperative wound pain,reduce wound secretio

关 键 词：外用重组人酸性成纤维细胞生长因子 低位肛瘘 术后创面愈合 

分 类 号：R657.16[医药卫生—外科学]