围生期孕妇B族链球菌、细小脲原体及沙眼衣原体感染相关性分析  

Association analysis of group B Streptococcus,Ureaplasma parvum and Chlamydia trachomatis infection in perinatal pregnant women

作　　者：张鸣菲 黄文波 刘玉兰 马占忠 ZHANG Mingfei;HUANG Wenbo;LIU Yulan;MA Zhanzhong(Reproductive Medicine Center,Yuebei People's Hospital,Shantou University Medical College,Guangdong Province,Shaoguan 512026,China)

机构地区：[1]汕头大学医学院附属粤北人民医院生殖医学中心,广东韶关512026

出　　处：《中国当代医药》2024年第28期123-126,共4页China Modern Medicine

基　　金：广东省韶关学院自然科学类研究项目(XJ2023004301)。

摘　　要：目的探讨孕妇B族链球菌(GBS)感染与细小脲原体(UP)和沙眼衣原体(CT)之间的相关性及其临床意义。方法选取2020年1月至2023年12月在粤北人民医院就诊的3302例围生期孕妇为研究对象,采用PCR-荧光探针法检测GBS、UP和CT的核酸;比较GBS阳性组和阴性组感染UP和CT的情况。结果在3302例孕妇中检出GBS阳性323例,GBS感染率为9.78%。GBS阳性组和阴性组分别检出UP(+)113例(34.98%)和1354例(45.45%),阴性组UP阳性率高于阳性组,差异有统计学意义(P<0.05)。GBS与UP感染无相关性(r=-0.039,P>0.05)。GBS阳性组与阴性组分别检出CT(+)9例和149例,两组的CT阳性率比较,差异无统计学意义(P>0.05)。GBS与CT感染无相关性(r=-0.002,P>0.05)。结论围生期孕妇GBS阴性的孕妇更容易发生UP的感染,但GBS与UP、CT感染均无相关性。临床医生需关注GBS阴性孕妇UP的感染情况,预防不良妊娠结局。Objective To explore the correlation of group B Streptococcus(GBS)infection in pregnant women with Ureplasma parvum(UP)and Chlamydia trachomatis(CT)and their clinical significance.Methods A total of 3302 perinatal pregnant women who received medical treatment at the Yubei People's Hospital from January 2020 to December 2023 were selected as the study subjects.PCR fluorescence probe method was used to detect nucleic acids in GBS,UP and CT.The infection of UP and CT between GBS positive and negative groups were compared.Results Positive GBS was detected in 323 of 3302 pregnant women,and the GBS infection rate was 9.78%.UP(+)113(34.98%)and 1354(45.45%)were detected in the negative group and the positive group,the UP positive rate of negative group was higher than that of positive group,the difference was statistically significant(P<0.05),but there was no correlation between GBS and UP infection(r=-0.039,P>0.05).CT(+)9 and 149 cases were detected in GBS positive and negative groups,respectively.There was no significant difference in CT positive rate between the two groups(P>0.05).GBS was not associated with UP infection(r=-0.002,P>0.05).Conclusion There is no association between GBS and UP infection or CT infection in perinatal pregnant women.Clinicians should pay attention to the infection of UP in GBS negative pregnant women to prevent adverse pregnancy outcomes.

关 键 词：B族链球菌 细小脲原体 沙眼衣原体 围生期 孕妇 

分 类 号：R711[医药卫生—妇产科学]