T细胞力学免疫学研究进展  

Advances in T Cell Mechanoimmunology

作　　者：吴松芳 娄继忠[1] WU Songfang;LOU Jizhong(Key Laboratory of Epigenetic Regulation and Intervention,Institute of Biophysics,Chinese Academy of Sciences,Beijing 100101,China)

机构地区：[1]中国科学院生物物理研究所,表观遗传调控与干预重点实验室,北京100101

出　　处：《医用生物力学》2024年第5期796-805,共10页Journal of Medical Biomechanics

基　　金：国家自然科学基金项目(T2394513,32090044)。

摘　　要：T细胞是获得性免疫的核心之一,T细胞受体(T cell receptor,TCR)对抗原的特异性识别是启动抗肿瘤、抗病毒免疫应答的关键过程。近年来的研究表明力在T细胞免疫反应中起着重要的调控作用,为力学免疫学这一新兴领域奠定了基础。本文重点讨论力协助TCR区分特异性抗原和自身非特异性抗原的机制,以及力在启动TCR跨细胞膜信号传导及触发T细胞激活过程中发挥的关键作用。总结了力学免疫学研究中新的生物物理单分子工具和先进的成像技术,这些工具的能够在分子和细胞尺度上深入揭示力作用的重要性。本文基于国内外专家团队的研究成果,并结合本团队研究工作,对力在T细胞功能中的作用进行总结探讨,为深入理解力学免疫学领域的前沿热点和探索新的研究方向提供系统框架。T cells play an essential role in adaptive immunity,and the specific recognition of antigens by T cell receptors(TCRs)is the key in initiating anti-tumor and antiviral immune responses.Recent studies have demonstrated that force plays an important regulatory role in T cell immune responses,laying the foundation for the emerging field of mechanoimmunology.In this review,the mechanisms by which force assists TCRs in distinguishing between specific antigens and non-specific antigens,as well as the critical role force plays in initiating TCR transmembrane signaling and triggering T cell activation are mainly discussed.The novel biophysical single-molecule tools and advanced imaging techniques that can deeply reveal the importance of mechanical forces at the molecular and/or cellular level are summarized.Based on the research results of domestic and foreign expert teams,combined with the research work of our team,this review summarizes and discusses the role of force in T cell function,so as to provide a system framework for deeply understanding the cutting-edge hotspots in the field of mechanoimunology and exploring new research directions.

关 键 词：T细胞受体 逆锁键 力学传导 单分子力谱 肿瘤免疫治疗 力学免疫学 

分 类 号：R318.01[医药卫生—生物医学工程]