基于细胞力传感器探索卵泡发育机制  

Mechanism of the Development of Follicles Based on Cellular Force Transducer

作　　者：杨青青 任冀峰 阮鑫 王鹏旭 董晓英[1] YANG Qingqing;REN Jifeng;RUAN Xin;WANG Pengxu;DONG Xiaoying(School of Chinese Medicine,Capital Medicine University,Beijing 100069,China;School of Biomedical Engineering,Capital Medicine University,Beijing 100069,China)

机构地区：[1]首都医科大学中医药学院,北京100069 [2]首都医科大学生物医学工程学院,北京100069

出　　处：《医用生物力学》2024年第5期992-997,共6页Journal of Medical Biomechanics

基　　金：北京市自然科学基金项目(7212162)。

摘　　要：细胞力传感器在卵泡正常发育过程中发挥着重要作用,它由整合素、黏着斑、信号通路和细胞骨架组成。在卵泡发育过程中,细胞力传感器能将力学刺激转化为生化信号,激活信号通路,使细胞骨架响应刺激,促进生殖细胞迁移、减数分裂和排卵。从力传感器在卵泡发育中的作用和相关信号通路等两方面探讨卵泡发育作用机制,为卵泡发育的深入研究提供新思路。Cellular force transducer plays a crucial role in normal development of the follicles,which consists of integrin,focal adhesion,signal pathways and cytoskeleton.In follicle development,cellular force transducer converts force stimulation into biochemical signal,and activates the signal pathways to make cytoskeleton respond to stimulation.This process promotes various biological functions of germ cells,such as migration,meiosis and ovulation.This review summarizes the mechanism of follicles’development from two aspects,the role of cellular force transducer in the development of follicles and the related signal pathways,so as to provide a new idea for the further study of follicle development.

关 键 词：细胞力传感器 卵泡发育 细胞骨架 

分 类 号：R318.01[医药卫生—生物医学工程]