BLUPmrMLM:A Fast mrMLM Algorithm in Genome-wide Association Studies  

作　　者：Hong-Fu Li Jing-Tian Wang Qiong Zhao Yuan-Ming Zhang 

机构地区：[1]College of Plant Science and Technology,Huazhong Agricultural University,Wuhan 430070,China

出　　处：《Genomics, Proteomics & Bioinformatics》2024年第3期55-67,共13页基因组蛋白质组与生物信息学报（英文版）

基　　金：supported by the National Natural Science Foundation of China(Grant Nos.32070557 and 32270673);the Huazhong Agricultural University Scientific&Technological Self-innovation Foundation,China(Grant No.2014RC020).

摘　　要：Multilocus genome-wide association study has become the state-of-the-art tool for dissecting the genetic architecture of complex and multiomic traits.However,most existing multilocus methods require relatively long computational time when analyzing large datasets.To address this issue,in this study,we proposed a fast mrMLM method,namely,best linear unbiased prediction multilocus random-SNP-effect mixed linear model(BLUPmrMLM).First,genome-wide single-marker scanning in mrMLM was replaced by vectorized Wald tests based on the best linear unbiased prediction(BLUP)values of marker effects and their variances in BLUPmrMLM.Then,adaptive best subset selection(ABESS)was used to identify potentially associated markers on each chromosome to reduce computational time when estimating marker effects via empirical Bayes.Finally,shared memory and parallel computing schemes were used to reduce the computational time.In simulation studies,BLUPmrMLM outperformed GEMMA,EMMAX,mrMLM,and FarmCPU as well as the control method(BLUPmrMLM with ABESS removed),in terms of computational time,power,accuracy for estimating quantitative trait nucleotide positions and effects,false positive rate,false discovery rate,false negative rate,and F1 score.In the reanalysis of two large rice datasets,BLUPmrMLM significantly reduced the computational time and identified more previously reported genes,compared with the aforementioned methods.This study provides an excellent multilocus model method for the analysis of large-scale and multiomic datasets.The software mrMLM v5.1 is available at BioCode(https://ngdc.cncb.ac.cn/biocode/tool/BT007388)or GitHub(https://github.com/YuanmingZhang65/mrMLM).

关 键 词：Genome-wide association study BLUP Multilocus model mrMLM Large-scale dataset 

分 类 号：Q811.4[生物学—生物工程]