总胆固醇水平与打鼾情况交互作用对贵州省侗族人群代谢综合征的影响  

Association of total cholesterol level and snoring condition interaction with metabolic syndrome in Dong ethnic minority,Guizhou

作　　者：肖斐 王媛 胡宇欣 周恩慧 申毅力 洪峰[1] XIAO Fei;WANG Yuan;HU Yu-xin;ZHOU En-hui;SHEN Yi-li;HONG Feng(School of Public Health,the Key Laboratory of Environmental Pollution Monitoring and Disease Control,Ministry of Education,Guizhou Medical University,Guiyang,Guizhou 561113,China)

机构地区：[1]贵州医科大学公共卫生与健康学院,环境污染与疾病监控教育部重点实验室,贵州贵阳561113

出　　处：《现代预防医学》2024年第20期3787-3792,共6页Modern Preventive Medicine

基　　金：国家重点研发计划课题(2017YFC0907301)。

摘　　要：目的研究贵州省30~79岁世居侗族人群总胆固醇(Total Cholesterol,TC)水平,打鼾情况分别与代谢综合征(Metabolic Syndrome,MetS)的关系,并进一步分析两者对MetS的交互作用。方法本研究数据来源于“西南区域少数民族聚集地世居自然人群队列研究”数据库,共纳入5815名贵州省30~79岁世居侗族人群,采用二分类logistic回归分析TC水平及打鼾情况分别与MetS的关系。构建相乘模型与相加模型用于评估TC水平与打鼾情况之间的交互作用与MetS的关联性。结果贵州省30~79岁世居侗族人群代谢综合征检出率为22.08%。在总人群中发现与TC水平<5.20 mmol/L的参与者相比,TC水平≥5.20 mmol/L与MetS患病情况呈正相关关系(OR=2.19,95%CI:1.93~2.49),此外,打鼾与MetS患病情况也呈正相关关系(OR=2.17,95%CI:1.19~2.47)。在总人群中TC水平与打鼾情况对MetS不存在相乘交互作用但存在相加交互作用(相对超额危险度=1.10,95%CI:0.41~1.79;归因比=0.25,95%CI:0.12~0.39;交互作用指数=1.49,95%CI:1.15~1.92)。结论在MetS的防控中,不仅要重视TC水平等生化指标,还应关注打鼾对疾病的影响。通过培养健康的生活方式,降低TC水平,改善打鼾情况,以期为MetS的管理和控制起到积极作用。Objective To investigate the relationship between total cholesterol(TC)levels,snoring condition with Metabolic Syndrome(MetS)in a population of 30-79 years old from the Dong ethnic minority in Guizhou Province,and to further analysethe interaction between the two on MetS.Methods The data of this study came from the database of the“Natural Population Cohort Study in the Gathering Places of Ethnic Minorities in Southwest China”,and a total of 5815 people of Dong ethnic group aged 30-79 years in Guizhou Province were included,and used binary logistic regression to analyse the associations of TC level and snoring condition with MetS,respectively.A multiplicative model and an additive model were constructed for assessing the association of the interaction between TC level and snoring condition with MetS.Results The detection rate of metabolic syndrome was 22.08%in the population of the hereditary Dong ethnic group aged 30-79 years in Guizhou Province.In the total population,TC levels≥5.20 mmol/L were found to be positively associated with MetS compared to participants with TC levels<5.20 mmol/L(OR=2.19,95%CI:1.93-2.49).In addition,snoring was positively associated with the MetS prevalence(OR:2.17,95%CI:1.19-2.47).There was no multiplicative but additive interaction between TC level and snoring condition on MetS in the total population(the relative excess risk due to interaction=1.10,95%CI:0.41-1.79;the attributable proportion due to interaction=0.25,95%CI:0.12-0.39;the synergy index=1.49,95%CI:1.15-1.92).Conclusion In the prevention and control of MetS,attention should be paid not only to biochemical indicators such as TC levels,but also to the effect of snoring on the disease.By cultivating a healthy lifestyle,TC levels can be reduced and snoring can be improved with a view to playing a positive role in the management and control of MetS.

关 键 词：代谢综合征 总胆固醇 打鼾 交互作用 

分 类 号：R589.2[医药卫生—内分泌]