柯里拉京在炎症性疾病中的作用及机制研究进展  

Research progress on the effects and mechanisms of corilagin in inflammatory diseases

作　　者：胡竞文 袁哲 杨晓雅 张惠 闫风连 HU Jing-wen;YUAN Zhe;YANG Xiao-ya;ZHANG Hui;YAN Feng-lian(Institute of Immunology and Molecular Medicine,College of Basic Medical,Jining Medical University,Jining 272067,China)

机构地区：[1]济宁医学院基础医学院免疫学与分子医学研究所,济宁272067

出　　处：《现代免疫学》2024年第5期449-453,共5页Current Immunology

基　　金：国家自然科学基金(82171810);山东省医药卫生科技发展计划项目(202202070388);山东省大学生创新训练计划项目(S202110443039);国家级大学生创新训练计划项目(S202010443005)。

摘　　要：炎症性疾病是由机体抵御刺激发生炎症反应后引发的一系列急性或慢性疾病,严重危害人类身体健康。具有多靶点免疫调节作用的中医药在多种炎症性疾病的治疗中具有重要作用。柯里拉京,是多种药用植物的活性成分,具有抗氧化、抗炎、保肝、抗病毒、抗高血压、抗感染和抗肿瘤等多种生物学和药理学活性,近来被广泛关注。但对于其在炎症性疾病中的作用还未有系统性认识。为了更好的开发和利用药用植物资源,该文综述了柯里拉京在多种炎症性疾病中的作用及机制,以期为其后续基础研究和临床应用提供参考。Inflammatory diseases are a series of acute or chronic diseases caused by inflammatory response to stimulation,which may seriously harm human health.Traditional Chinese medicine,which has multiple targets in immunomodulatory processes,plays a key role in the treatment of various inflammatory diseases.Corilagin is one of the major bioactive compounds in many medicinal plants.It has a variety of biological and pharmacological activities,including anti-oxidation,anti-inflammatory,liver protection,anti-virus,anti-hypertension,anti-infection,and anti-tumor.It has attracted extensive attention in recent years.However,there is a lack of systematic understanding of the role corilagin plays in inflammatory diseases.To better develop and utilize the medicinal plant resources in China,this review summarizes the role and related mechanism of corilagin in various inflammatory diseases.It will provide references for both follow-up basic research and clinical application of corilagin.

关 键 词：柯里拉京 炎症性疾病 机制 

分 类 号：R392.1[医药卫生—免疫学]