辅酶Q10柔性脂质体凝胶的制备及其评价  

The preparation and evaluation of Coenzyme Q10 flexible liposome gel

作　　者：张玉洁 钟玮 王中彦 孙铭洋 ZHANG Yujie;ZHONG Wei;WANG Zhongyan;SUN Mingyang(School of Pharmacy,Shenyang Pharmaceutical University,Shenyang 110016,China;School of Traditional Chinese Medica,Shenyang Pharmaceutical University,Shenyang 110016,China)

机构地区：[1]沈阳药科大学药学院,辽宁沈阳110016 [2]沈阳药科大学中药学院,辽宁沈阳110016

出　　处：《沈阳药科大学学报》2024年第10期1306-1315,1331,共11页Journal of Shenyang Pharmaceutical University

摘　　要：目的将辅酶Q10制备成柔性脂质体凝胶,考察其体外特性与抗衰老效果.方法以卡波姆940为凝胶基质,甘油和丙二醇为保湿剂制备凝胶剂,以皮肤滞留量为指标,采用正交试验设计优化辅酶Q10柔性脂质体凝胶处方,并对其外观形态、体外释放、体外透皮、流变学、抗衰老药效学进行考察.结果辅酶Q10柔性脂质体凝胶处方为:卡波姆940的比例为0.5%,保湿剂的比例为10%,其中甘油与丙二醇为质量比1∶1,三乙醇胺的比例为0.4%;凝胶质地均匀细腻,稳定性良好;体外释放结果表明,辅酶Q10柔性脂质体的体外释放量高于辅酶Q10柔性脂质体凝胶和辅酶Q10市售面霜;体外透皮结果表明,辅酶Q10柔性脂质体的透皮量高于辅酶Q10柔性脂质体凝胶,但皮肤滞留量低于辅酶Q10柔性脂质体凝胶;流变学结果表明,制备的凝胶属于假塑性流体;药效学结果表明,辅酶Q10柔性脂质体凝胶具有增加皮肤的抗氧化活性,增加皮肤胶原纤维含量,延缓皮肤衰老的作用.结论辅酶Q10柔性脂质体凝胶可以提高皮肤抗氧化能力,延缓皮肤衰老.Objective Coenzyme Q10 was prepared into flexible liposome gel,and its in vitro characteristics and anti-aging effect were investigated.Methods The gel agent was prepared with carbomer 940 as the gel matrix,glycerol and propylene glycol as the humectant,and the skin retention amount was used as the index,the orthogonal experimental design was used to optimize the prescription of coenzyme Q10 flexible liposomes,and its appearance morphology,rheology,in vitro release,in vitro transdermal and anti-aging pharmacodynamics were investigated.Results Coenzyme Q10 flexible liposome gel prescriptions were:Carbomer 940 ratio of 0.5%,moisturizer ratio of 10%,glycerol to propylene glycol ratio of 1∶1,triethanolamine ratio of 0.4%.The gel texture was uniform and delicate,and the rheological results showed that the prepared gel belonged to a pseudoplastic fluid.The in vitro release of coenzyme Q10 flexible liposome was higher than that of coenzyme Q10 flexible liposome gel and coenzyme Q10 facial cream.The results showed that the transdermal amount of coenzyme Q10 flexible liposome was higher than that of coenzyme Q10 flexible liposome gel,but the skin retention was lower than that of Coenzyme Q10 flexible liposome gel.The pharmacodynamic results showed that coenzyme Q10 flexible liposome gel can increase the antioxidant activity of skin,increase the content of skin collagen fiber and delay skin aging.Conclusion coenzyme Q10 flexible liposome gel can improve skin antioxidant capacity and delay skin aging.

关 键 词：辅酶Q10 脂质体凝胶 流变学 抗衰老 正交试验 

分 类 号：R94[医药卫生—药剂学]