叶酸代谢酶基因多态性及HHcy与CKD相关性的研究进展  

Research advances of folate metabolic enzyme gene polymorphism and the relationship between HHcy and CKD

作　　者：潘娅 宋沧桑[1,2] 李兴德[1,2] 王国徽[2] 毛盼盼 张函舒[2] PAN Ya;SONG Cangsang;LI Xingde;WANG Guohui;MAO Panpan;ZHANG Hanshu(Department of Pharmacy,Affiliated Ganmei Hospital,Kunming Medical University,Yunnan Kunming 650500,China;Department of Pharmacy,Kunming First People’s Hospital,Yunnan Kunming 650224,China)

机构地区：[1]昆明医科大学附属甘美医院药学部,云南昆明650500 [2]昆明市第一人民医院药学部,云南昆明650224

出　　处：《中国医院药学杂志》2024年第19期2298-2302,共5页Chinese Journal of Hospital Pharmacy

基　　金：云南省卫生健康委员会医学领军人才培养项目(编号:L-2018012);昆明市医学科技领军人才培养项目[编号:2023-SW(领军)-04];云南省临床药学中心建设项目(昆明市第一人民医院2022年—2025年)。

摘　　要：慢性肾脏病(chronic kidney disease,CKD)是世界卫生的重大问题之一,全球患病率高达13.4%。研究表明,高同型半胱氨酸血症(hyper homocysteinermia,HHcy)是肾脏疾病的相关危险因素,与CKD的发生发展有着密切关系。而5-甲基四氢叶酸是同型半胱氨酸(homocysteinermia,Hcy)代谢相关酶的必需辅助因子,Hcy在向蛋氨酸的转化中受到叶酸代谢酶基因多态性的影响。已有临床实践通过补充叶酸有效降低Hcy水平,减轻HHcy导致的肾脏损伤,延缓CKD的进展。但目前叶酸及其代谢酶对CKD发生发展的作用尚不明确。该文就叶酸代谢酶基因多态性及HHcy与CKD的发生发展进行概述,为伴有HHcy的CKD患者疾病防治提供理论依据,从而降低终末期肾病和心脑血管患疾的风险。As a major health hazard with a global prevalence rate of 13.4%,chronic kidney disease(CKD)is associated with an elevated risk of developing end-stage kidney disease(ESKD)and cardiocerebrovasculopathy.Growing studies have indicated that hyper homocysteinemia(HHcy)is a risk factor for kidney disease.It is correlated closely with the occurrence and development of CKD.And 5-methyltetrahydrofolic acid is an essential cofactor of related enzymes in the metabolism of homocysteinemia(Hcy).Hcy is affected by folate metabolism enzyme gene polymorphism during the transformation into methionine.Folic acid supplementation may effectively lower the level of Hcy,blunt kidney damage caused by HHcy and delay the progression of CKD.However,the effects of folic acid and its metabolic enzymes on the occurrence and development of CKD have remained elusive.This review focused upon folate metabolism enzyme gene polymorphisms and the occurrence and development of HHcy/CKD to provide theoretical rationales for preventing and treating CKD patients with HHcy.

关 键 词：叶酸 代谢酶 基因多态性 同型半胱氨酸 慢性肾脏病 

分 类 号：R969[医药卫生—药理学]