呋塞米口服液的稳定性及有效期预测  

Stability and validity prediction of furosemide oral solution

作　　者：时涛 杨艺 冯锁民[1] 王懿[3] 李惠民[3] 张纯玮 赵泽浩 郑盈 SHI Tao;YANG Yi;FENG Suomin;WANG Yi;LI Huimin;ZHANG Chunwei;ZHAO Zehao;ZHENG Ying(College of Pharmacy,Xi′an Medical University,Xi′an 710021,China;Central Hospital of Baoji City,Baoji 710075,China;Shangluo Vocational and Technical College,Shangzhou 726000,China)

机构地区：[1]西安医学院药学院,陕西西安710021 [2]宝鸡市中心医院,陕西宝鸡721008 [3]商洛职业技术学院,陕西商州726000

出　　处：《化工科技》2024年第5期55-58,共4页Science & Technology in Chemical Industry

基　　金：2023年国家级、陕西省及西安医学院校级大学生创新创业训练计划项目(2023118423005,S2023118423005,121523005);西安医学院科技能力提升项目(2022NLTS068);西安医学院第五批校级重点建设学科-药学项目(12202304);商洛职业技术学院2023年度规划课题项目(JYKT202307)。

摘　　要：探索影响呋塞米口服液稳定性的因素,并预测其有效期。采用加速稳定性实验的方法,研究温度、光照、存放时间等因素对呋塞米口服液稳定性的影响,确定降解反应的级数,计算25℃的降解速度常数(K_(25℃))和有效期。结果表明,高温、光照、时间对呋塞米口服液稳定性影响较大,降解反应为一级;t=25℃,有效期为305 d;呋塞米口服液需棕色玻璃瓶灌装,阴凉避光保存。In order to explore the factors that affect the stability of furosemide oral solution and predict its validity,an accelerated testing method was used.The methods were used to study the effects of temperature,light and storage time on the stability of furosemide oral solution,and calculate the degradation rate constant(K_(25℃)) and validity period of furosemide oral solution at 25℃.The results indicated that the furosemide oral solution was unstable in case of light,temperature,and gradually decomposed with time.The degradation reaction is one grade,and the validity is 305 days at 25℃.It was recommended that the furosemide oral solution should be filled in a brown glass bottle and stored in a cool,dark place.

关 键 词：呋塞米口服液 稳定性 有效期 降解反应 

分 类 号：R944.1[医药卫生—药剂学]