富血小板血浆注射治疗膝骨关节炎疗效的相关因素分析  

Factors Associated with The Efficiency of Platelet-Rich Plasma Injection Among Patients with Knee Osteoarthritis

作　　者：林彩娜[1] 郑耀超 刘黎嘉琪 易伟民[1] 伍少玲[1] LIN Cai-na;ZHENG Yao-chao;LIU Li-jia-qi;YI Wei-min;WU Shao-ling(Sun Yat-Sen Memorial Hospital,Sun Yat-Sen University.Guangzhou,510120)

机构地区：[1]中山大学孙逸仙纪念医院康复医学科,510120

出　　处：《岭南急诊医学杂志》2024年第5期526-528,534,共4页Lingnan Journal of Emergency Medicine

基　　金：广东省广州市神经调控和再生医学康复重点实验室(2024A03J0699);广东省康复医学临床医学研究中心项目(2023B110003)。

摘　　要：目的:探讨影响富血小板血浆(PRP)注射治疗膝骨性关节炎(KOA)疗效的相关因素。方法:选取82例KOA患者进行PRP治疗。采用西安大略和麦克马斯特大学骨关节炎指数(WOMAC)、视觉模拟评分(VAS)、基于X线的Kellgren-Lawrence(K-L)分级评估膝关节情况,并将治疗前后的WOMAC变化作为疗效的评价指标。结果:PRP治疗可显著降低WOMAC分数。单因素分析显示治疗前K-L分级、病程与PRP治疗后WOMAC分数改变有统计学意义。多因素线性回归显示治疗前高VAS评分、治疗前低K-L分级、男性是影响PRP治疗的有利因素,相关性显示K-L分级与WOMAC改变呈负相关关系。结论:重度疼痛、K-L分级轻中度的男性KOA患者是影响PRP治疗的有利因素。Objective:To identify the factors that influence the effect of PRP in the treatment of KOA.Methods:PRP was performed in 82 patients who were diagnosed with KOA.A Western Ontario and McMaster Universities Osteoarthritis Index(WOMAC)was used to score the level of KOA.Visual Analogue Scale(VAS),X-ray and subsequent Kellgren-Lawrence(K-L)grading evaluation were performed before the treatment.The change of WOMAC before and after treatment was used to evaluate the effect of PRP.Results:WOMAC decreased after PRP therapy.Univariate analysis showed that K-L grade before treatment,course of disease and WOMAC score after PRP treatment had statistical significance.Multifactor linear regression showed that high VAS score before treatment,low K-L grade before treatment and male patients were protective factors affecting PRP treatment,and correlation showed that K-L grade was negatively correlated with WOMAC changes.Conclusion:Male KOA patients with severe pain and mild to moderate K-L rating were favorable factors for PRP treatment.

关 键 词：富血小板血浆 膝骨关节炎 Kellgren-Lawrence分级 回归分析 

分 类 号：R684.3[医药卫生—骨科学]