小反刍兽疫免疫抗体监测的Meta分析  

Meta-analysis of post-vaccination antibody against peste des petits puminants virus

作　　者：王艺 沈鹏 钱莺娟[1] 蔡畅 常星 韩秀琚[2] 徐蛟 郑龙三 王志亮[2] WANG Yi;SHEN Peng;QIAN Yingjuan;CAI Chang;CHANG Xing;HAN Xiuju;XU Jiao;JUNG Yongsam;WANG Zhiliang(College of Veterinary Medicine,Nanjing Agricultural University/MOE Joint International Research Laboratory of Animal Health and Food Safety/Jiangsu Foreign Expert Workshop,Nanjing 210095,China;China Animal Health And Epidemiology Center/WOAH Reference Laboratory for Peste des Petits Ruminants/FAO Reference Center for Peste des Petits Ruminants,Qingdao 266000,China;College of Animal Science and Technology·Animal Medical College,Zhejiang A&F University,Hangzhou 311300,China;School of Information Technology,College of Science,Technology,Engineering and Mathematics,Murdoch University,Perth 6150,Australia)

机构地区：[1]南京农业大学动物医学院/教育部动物健康与食品安全国际合作联合实验室/江苏省外国专家工作室,江苏南京210095 [2]中国动物卫生与流行病学中心/世界动物卫生组织小反刍兽疫参考实验室/联合国粮农组织小反刍兽疫参考中心,山东青岛266000 [3]浙江农林大学动物科技学院·动物医学院,浙江杭州311300 [4]默多克大学信息技术学院理学部,澳大利亚珀斯6150

出　　处：《畜牧与兽医》2024年第11期100-108,共9页Animal Husbandry & Veterinary Medicine

基　　金：国家重点研发计划项目(2022YFD1800500)。

摘　　要：小反刍兽疫(PPR)是我国计划要消灭的重大外来动物疫病,对于实施疫苗免疫预防的省份或地区,必须确保免疫覆盖率和免疫抗体合格率,才能有效阻断病毒的传播。我国在春防、秋防期间,会组织开展免疫抗体监测活动,对抗体水平不高的场户及时开展补免工作。为综合评价PPR的群体免疫情况,利用荟萃(Meta)分析方法对已发表的文献进行了梳理分析。通过关键词匹配和全文阅读,共有59篇文献符合要求纳入分析,包含样品252048份,抗体平均阳性率为85%(95%CI:83%~87%)。通过进行亚组分析和Wilcoxon显著性检验,发现山东省和江苏省的抗体阳性率明显高于其余省份;不同场户类型之间,规模场的抗体阳性率明显高于散养户;不同检测方法之间抗体阳性率无显著性差异。本研究的分析结果为PPR根除计划的实施提供了科学依据。Peste des petits ruminants(PPR)is a significant foreign animal disease that China plans to eradicate.For provinces or regions implementing vaccine immunization prevention,it is essential to ensure both the immunization coverage rate and the qualified rate of immunization antibodies so as to effectively block the spread of the virus.Following the vaccination campaign conducted in spring and autumn,herd immunity will be monitored by the authorities,and herds with lower antibody levels will be revaccinated timely.To comprehensively evaluate the herd immunity of PPR,a Meta-analysis method was used in this study to sort and analyze published literatures.A total of 59 papers met the requirements for inclusion analysis through keyword matching and full text reading,including 252048 samples with the average antibody positive rate of 85%(95%CI:83%-87%).It was found that the antibody positivity rates in Shandong Province and Shanghai City were significantly higher than those in other provinces in China through subgroup analysis and Wilcoxon significant tests.Among different farming types,the average antibody positivity rates in large-scaled farms was significantly higher than that in small free-ranged farms.However,there was no significant difference in antibody positive rates among the different tests.The results of the present study provide a scientific basis for the implementation of the PPR eradication program.

关 键 词：小反刍兽疫 免疫 抗体 META分析 

分 类 号：S855.3[农业科学—临床兽医学]