无催化剂直接合成单取代脲的研究  

A Practically Simple and Catalyst Free Synthesis of Monosubstituted Ureas

作　　者：翁玉芳 蔡鸿飞 郑人华[2] WENY Yu-fang;CAI Hong-fei;ZHENG Ren-hua(Hangzhou QingYue Pharmaceutical Technology Co.,Ltd.,Hangzhou 310023,China;College of Pharmaceutical and Chemical Engineering,Taizhou University,Taizhou 318001,China)

机构地区：[1]杭州青玥医药科技有限公司,浙江杭州310023 [2]台州学院医药化工学院,浙江台州318001

出　　处：《精细化工中间体》2024年第5期15-18,共4页Fine Chemical Intermediates

摘　　要：报道了一种以哌啶类化合物和尿素一步反应直接合成单取代脲的方法,并探究反应温度、反应时间及投料比对收率的影响。方法无需外加催化剂、操作简单安全、收率高。目标产物结构经^(1)H NMR、^(13)C NMR和IR确证。A method for the synthesis of monosubstituted ureas is reported.Monosubstituted urea derivatives were directly synthesized by reacting urea with various piperidine compounds without catalysis.The effects of reaction temperature,reaction time and feed ratio on the yields were investigated.The method is simple and safe to operate without the need for additional catalysts,and it results in a high yield.The structures of the target products were identified by^(1)H NMR,^(13)C NMR and IR.

关 键 词：单取代脲 缩合反应 哌啶类化合物 

分 类 号：TQ21[化学工程—有机化工]