不同饮食摄入量与心肌梗死发病风险的因果关系:一项两样本孟德尔随机化研究  

Causal relationship between different dietary intake and the risk of myocardial infarction:a two-sample Mendelian randomization study

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作  者:石晶 徐茜 李佳媚[1] 高文艺 何梦菲 王岗[1] Shi Jing;Xu Xi;Li Jiamei;Gao Wenyi;He Mengfei;Wang Gang(Department of Critical Care Medicine,the Second Affiliated Hospital of Xi′an Jiaotong University,Xi′an 710004,China)

机构地区:[1]西安交通大学第二附属医院重症医学科,陕西西安710004

出  处:《中国急救医学》2024年第11期965-971,共7页Chinese Journal of Critical Care Medicine

基  金:西安交通大学第二附属医院IIT临床研究基金项目(2011)。

摘  要:目的评估不同饮食摄入量与心肌梗死发病风险之间是否存在因果关系。方法从国际公开数据库中获取全基因组关联研究(GWAS)相关数据,8类(包括饮品、谷薯类、蔬菜水果、肉蛋类、乳制品、豆类、坚果类和盐)共33种饮食摄入量相关遗传变异的单核苷酸多态性(SNPs)来自于英国生物银行(UK Biobank),心肌梗死相关SNPs来自于芬兰数据库(FinnGen)。采用两样本孟德尔随机化(MR)方法评估暴露因素(饮食摄入量)和结局事件(心肌梗死)之间的因果关系。逆方差加权法作为主要的MR分析方法,敏感性分析采用Cochrane′s Q检验、MR-Egger回归及MR多效残差和离群值(MR-PRESSO)检验。结果水果干(OR=0.575,95%CI 0.420~0.788,P<0.001)、贝类海鲜(OR=0.392,95%CI 0.156~0.987,P=0.047)和奶酪(OR=0.690,95%CI 0.560~0.850,P<0.001)摄入量增加与心肌梗死发病风险呈负相关。结论水果干、贝类海鲜和奶酪摄入量与心肌梗死发病风险之间存在因果关系,摄入量增加可能降低心肌梗死发病风险。Objective To explore whether there is a causal relationship between different dietary intake and the risk of myocardial infarction.Methods Genome-wide association study(GWAS)data were obtained from international public databases.A total of 33 single nucleotide polymorphisms(SNPs)associated with dietary intake in 8 categories(including drinks,cereals,vegetables and fruits,meat and eggs,dairy products,beans,nuts and salt)were obtained from the UK Biobank.SNPs associated with myocardial infarction were obtained from FinnGen.A two-sample Mendelian randomization(MR)method was used to assess the causal relationship between the exposure factor(dietary intake)and the outcome event(myocardial infarction).Inverse variance weighted was used as the main analysis method,and Cochrane′s Q test,MR-Egger regression,MR pleiotropy residual sum and outlier(MR-PRESSO)test were used for sensitivity analysis.Results Dried fruit intake(OR=0.575,95%CI 0.420-0.788,P<0.001),shellfish intake(OR=0.392,95%CI 0.156-0.987,P=0.047)and cheese intake(OR=0.690,95%CI 0.560-0.850,P<0.001)showed negative relationship with a risk of myocardial infarction.Conclusions There was a causal relationship of dried fruit intake,shellfish intake and cheese intake with the onset of myocardial infarction,and their increased intake may reduce the risk of myocardial infarction.

关 键 词:饮食摄入量 心肌梗死 孟德尔随机化 

分 类 号:R542.22[医药卫生—心血管疾病]

 

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