柴胡桂枝干姜汤治疗上热下寒型失眠临床研究  

Clinical Study on Bupleurum and Cinnamon Twig and Dried Ginger Decoction in the Treatment of Insomnia with Upper Heat and Lower Cold Syndrome

作　　者：时高波[1] 万海娇 卢亚奇 康进忠 SHI Gaobo;WAN Haijiao;LU Yaqi;KANG Jinzong(Anyang Hospital of Traditional Chinese Medicine,Anyang,Henan,China,455002;The Second People′s Hospital of Anyang,Anyang,Henan,China,455002)

机构地区：[1]安阳市中医院,河南安阳455002 [2]安阳市第二人民医院,河南安阳455002

出　　处：《河南中医》2024年第11期1645-1649,共5页Henan Traditional Chinese Medicine

基　　金：全国名老中医药专家康进忠传承工作室建设项目{国中医药人教函【2022】75号};安阳市科技发展计划项目(2023C01SF182)。

摘　　要：目的:观察柴胡桂枝干姜汤治疗上热下寒型失眠的临床疗效。方法:选择2023年4—10月安阳市中医院脑病三科门诊诊治的100例上热下寒型失眠患者,按照随机数字表法分为对照组和试验组,每组各50例。对照组给予艾司唑仑片治疗,试验组给予柴胡桂枝干姜汤加减治疗。比较两组患者的临床疗效、不良反应积分及治疗前后中医证候积分、匹兹堡睡眠治疗指数、世界卫生组织生存质量测定量表简表(the world health organization quality of life scale,WHOQOL-BREF)积分变化情况。结果:两组患者治疗后中医证候积分低于本组治疗前,且治疗后试验组低于对照组(P<0.05)。试验组有效率为92.0%,高于对照组的86.0%,差异有统计学意义(P<0.05)。两组患者治疗后匹兹堡睡眠指数低于本组治疗前,且治疗后试验组低于对照组(P<0.05)。两组患者治疗后WHOQOL-BREF评分高于本组治疗前,且治疗后试验组高于对照组(P<0.05)。对照组不良反应积分为(2.72±0.73)分,试验组不良反应积分为(0.60±0.67)分,差异具有统计学意义(P<0.05)。结论:柴胡桂枝干姜汤加减治疗上热下寒型失眠临床疗效确切,可改善患者的临床症状,提高睡眠质量及生活质量。Objective:To observe the clinical efficacy of Bupleurum and Cinnamon Twig and Dried Ginger Decoction on insomnia with upper heat and lower cold syndrome.Methods:A total of 100 patients with insomnia of the upper heat and lower cold type treated at the No.3 Neurology Clinic of Anyang Hospital of Traditional Chinese Medicine from April to October 2023 were selected and randomly divided into the control group and the experimental group,with 50 cases in each group.The control group received treatment with Estazolam Tablets,while the experimental group was treated with Modified Bupleurum and Cinnamon Twig and Dried Ginger Decoction.The clinical efficacy,adverse reaction scores,changes in TCM syndrome scores,Pittsburgh Sleep Quality Index(PSQI),and the World Health Organization Quality of Life Scale Brief Version(WHOQOL-BREF)scores before and after treatment were compared between the two groups.Results:After treatment,TCM syndrome scores in both groups were lower than those before treatment,with the experimental group having lower scores than the control group(P<0.05).The effective rate of the experimental group was 92.0%,significantly higher than the control group′s 86.0%(P<0.05).The PSQI score in both groups was lower than that before treatment,with the experimental group′s lower than that of the control group(P<0.05).WHOQOL-BREF score was higher than that before treatment in both groups,with the experimental group′s higher than that of the control group(P<0.05).The adverse reaction score in the control group was(2.72±0.73),while that in the experimental group was(0.60±0.67),showing a significant difference between the two groups(P<0.05).Conclusion:Modified Bupleurum and Cinnamon Twig and Dried Ginger Decoction is effective in treating insomnia with upper heat and lower cold syndrome,can improve clinical symptoms,sleep quality,and quality of life in patients.

关 键 词：失眠 上热下寒证 柴胡桂枝干姜汤 《伤寒论》 张仲景 

分 类 号：R256.23[医药卫生—中医内科学]