AGT-M235T及eNOS-T786C基因多态性与急性心肌梗死的相关研究  

Correlation between AGT-M235T and eNOS-T786C gene polymorphisms and acute myocardial infarction

作　　者：黄朝任 邹光美 罗宇飞 宾广健 杨韩燕 陆日秋 HUANG Chaoren;ZOU Guangmei;LUO Yufei;BIN Guangjian;YANG Hanyan;LU Riqiu(Department of Clinical Laboratory,Traditional Chinese Medicine Hospital of Yulin,Guangxi,Yulin 537000,China;Department of Clinical Laboratory,the First People’s Hospital of Yulin,Guangxi,Yulin 537000,China)

机构地区：[1]广西壮族自治区玉林市中医医院检验科,广西玉林537000 [2]广西壮族自治区玉林市第一人民医院检验科,广西玉林537000

出　　处：《中国医药科学》2024年第19期12-16,共5页China Medicine And Pharmacy

基　　金：广西壮族自治区玉林市科学研究与技术开发计划项目(玉市科20220605)。

摘　　要：目的探讨血管紧张素原(AGT)-M235T、内皮型一氧化氮合酶(eNOS)-T786C基因多态性与急性心肌梗死(AMI)的相关性。方法选取2021年7月至2023年7月在玉林市中医医院就诊的AMI患者200例作为AMI组,同期体检健康者200名作为对照组,比较两组的基因型及等位基因频数的差异。结果AMI组男女间的eNOS-T786C基因型及等位基因频数比较,差异有统计学意义(P<0.05);对照组男女间的AGTM235T基因型、AGT-M235T等位基因及eNOS-T786C基因型频数比较,差异有统计学意义(P<0.05)。两组女性的eNOS-T786C基因型及等位基因频数比较,差异有统计学意义(P<0.05)。分别以GG和TT基因型作为参照进行二元logistic回归分析,结果表明AA及CC基因型可能是AMI患病的危险因素(AA:OR=2.281,P<0.05;CC:OR=2.934,P<0.05),而GA基因型可能是AMI患病的保护因素(OR=0.803,P<0.05)。结论AGT-M235T的AA基因型及eNOS-T786C的CC基因型与AMI易感性密切相关,临床需要重视AMI患者相关基因型的危险因素及保护因素。Objective To explore the correlation between the Angiotensinogen(AGT)-M235T and endothelial nitric oxide synthase(eNOS)-T786C gene polymorphisms with acute myocardial infarction(AMI).Methods A study was conducted comparing the genotype and allele frequencies between 200 patients diagnosed with acute myocardial infarction(AMI)who sought treatment at the Traditional Chinese Medicine Hospital of Yulin between July 2021 and July 2023,and 200 healthy individuals who received physical examinations during the same timeframe.Results The frequency of eNOS-T786C genotypes and alleles between males and females in the AMI group showed statistically significant differences(P<0.05).The frequency of AGT-M235T genotype,AGT-M235T allele,and eNOS-T786C genotype between males and females in the control group showed statistically significant differences(P<0.05).The frequency of eNOS-T786C genotypes and alleles in two groups of women showed a statistically significant difference(P<0.05).Binary logistic regression analysis,using GG and TT genotypes as reference,compared the AMI group with the control group,AA and CC genotypes may be risk factors for AMI(AA:OR=2.281,P<0.05;CC:OR=2.934,P<0.05),while GA genotype may be a protective factor for AMI(OR=0.803,P<0.05).Conclusion AA genotype of AGT-M235T and CC genotype of eNOS-T786C are closely related to the susceptibility to AMI,so it is necessary to pay attention to the risk factors and protective factors of rel ated genotypes in patients with AMI.

关 键 词：血管紧张素原 内皮型一氧化氮合酶 基因多态性 急性心肌梗死 危险因素 

分 类 号：R542.22[医药卫生—心血管疾病]