传统制剂滑膜灵颗粒的提取工艺研究  

Study on the extraction process of traditional preparation of Hua Mo Ling Granules

作　　者：林诗瑶 王建荣 王西林 林忠洲 张玉琴[2] LIN Shiyao;WANG Jianrong;WANG Xilin;LIN Zhongzhou;ZHANG Yuqin(Fuzhou Second General Hospital,Fujian,Fuzhou 350007,China;Fujian University of Traditional Chinese Medicine,Fujian,Fuzhou 350007,China)

机构地区：[1]福州市第二总医院,福建福州350007 [2]福建中医药大学,福建福州350007

出　　处：《中国医药科学》2024年第19期62-64,113,共4页China Medicine And Pharmacy

基　　金：福建省中医药科研项目(2021zyyj60)。

摘　　要：目的优选滑膜灵颗粒的提取工艺。方法利用单因素考察法,分别对苍术挥发油成分及滑膜灵颗粒全方的提取工艺进行研究,从提取时间、料液比、提取次数、浸泡时间等因素考察,优选最佳提取工艺。结果滑膜灵颗粒中苍术挥发油的提取工艺为苍术粉碎度为80目,料液比1∶15,浸泡时间和蒸馏时间均为2 h;全方的提取工艺为提取时间60 min,料液比1∶10,提取次数2次。结论结合考虑经济效益和操作性,该方法稳定可靠,能为后期开发滑膜灵颗粒提供依据,为其他中药制剂研发提供思路。Objective To optimize the extraction process of Hua Mo Ling Granules.Methods The extraction process of the component of volatile oil from Atractylodes Lancea and the whole formula of Hua Mo Ling granules were investigated using the single factor test method,respectively,from factors of extraction time,material-liquid ratio,number of times of extraction,and soaking time,to optimize the best extraction process.Results The extraction process of the volatile oil from Atractylodes Lancea in Hua Mo Ling Granules consisted of a crushing degree for Atractylodes Lancea of 80 mesh,a material-liquid ratio of 1∶15,soaking time of 2 h,and distillation time of 2 h.The extraction process of the whole formula consisted of extraction time of 60 min,a material-liquid ratio of 1∶10,and 2 times of extraction.Conclusion Taking the economic benefits and operability into consideration,this method is stable and reliable.It can provide a basis for the later development of Hua Mo Ling Granules and support ideas for the development of other Chinese medicinal preparations.

关 键 词：滑膜灵颗粒 挥发油 提取工艺 中药制剂 

分 类 号：R283[医药卫生—中药学]