基于“肠心轴”探讨中药调节肠道菌群治疗心力衰竭的研究进展  

Research Progress of TCM Regulating Intestinal Flora in Treatment of Heart Failure Based on"Gut-Heart Axis"

作　　者：刘妍宏 魏至扬 胡景璇 范增光 伍建光[2] LIU Yanhong;WEI Zhiyang;HU Jingxuan;FAN Zengguang;WU Jianguang(Jiangxi University of Chinese Medicine,Nanchang Jiangxi China 330004;The Affiliated Hospital to Jiangxi University of Chinese Medicine,Nanchang Jiangxi China 330006)

机构地区：[1]江西中医药大学,江西南昌330004 [2]江西中医药大学附属医院,江西南昌330006

出　　处：《中医学报》2024年第11期2282-2289,共8页Acta Chinese Medicine

基　　金：江西省自然科学基金项目(20224BAB216097);中国中医科学院科技创新工程学部委员学术传承与传播专项项目(CI2022E011XB);2022年度江西中医药大学校级研究生创新专项资金项目(JZYC22S37)。

摘　　要：心力衰竭是各种心血管疾病的终末期阶段,其高患病率及死亡率严重威胁人类的健康。越来越多的证据表明,肠道微生物群失调、肠道屏障功能障碍和肠道微生物群代谢物与心力衰竭密切相关。中药单体及中药复方具有多通路、多靶点治疗的特点,能够对机体进行整体调节,影响机体多个系统的生理功能。中药通过调控“肠心轴”治疗心力衰竭符合中医整体观念。中药方剂如葛根芩连汤、黄连解毒汤、四妙勇安汤等能通过调控肠道菌群及其代谢产物治疗心力衰竭。Heart failure is the end-stage stage of various cardiovascular diseases,and its high prevalence and mortality seriously threaten human health.Accumulating evidence suggests that gut microbiota dysbiosis,gut barrier dysfunction,and gut microbiota metabolites are strongly associated with heart failure.TCM monomers and TCM compounds have the characteristics of multi-channel and multi-target therapy,which can regulate the body as a whole and affect the physiological functions of multiple systems of the body.The treatment of heart failure by regulating the"gut-heart axis"with traditional Chinese medicine is in line with the overall concept in traditional Chinese medicine.Traditional Chinese medicine formulas such as Gegen Qinlian Decoction,Huanglian Jiedu Decoction,and Simiao Yong′an Decoction can treat heart failure by regulating the intestinal flora and its metabolites.

关 键 词：心力衰竭 “肠心轴” 肠道菌群 葛根芩连汤 黄连解毒汤 四妙勇安汤 

分 类 号：R256.29[医药卫生—中医内科学]