从心肾论治血管性痴呆  

Treatment of Vascular Dementia from Perspective of Heart and Kidney

作　　者：蒋思佳 顾耘[1] JIANG Sijia;GU Yun(Longhua Hospital Shanghai University of Traditional Chinese Medicine,Shanghai China 200032)

机构地区：[1]上海中医药大学附属龙华医院,上海200032

出　　处：《中医学报》2024年第11期2370-2375,共6页Acta Chinese Medicine

基　　金：2022年上海市名老中医药专家学术经验研究工作室建设项目(SHGZS-202241)。

摘　　要：血管性痴呆的主要病机为肾精不足,重要病因为心气不足,基本病机为心肾不交。痰、瘀等病理产物相互作用,共同损伤脑络发展为痴呆。中医补肾调心法可以通过改善神经炎症、减轻氧化应激、增加细胞自噬等途径改善认知功能,且中药具有多成分、多靶点的优势,单味药及复方可同时作用于血管性痴呆的多个靶点,调控多个基因的表达,改善认知功能障碍。The main pathogenesis of vascular dementia is Kidney Essence insufficiency.The important cause of the disease is the deficiency of Heart Qi,and the basic pathogenesis is Heart-Kidney non-communication.At the same time,other pathological products such as Phlegm and stasis interact with each other to jointly damage the brain network and develop dementia.Kidney tonifying and Heart regulating method of Chinese medicine can improve the cognitive function by improving neuroinflammation,reducing oxidative stress,and increasing autophagy.Moreover,traditional Chinese medicine has the advantages of multiple components and multiple targets,and single herbs and compound prescriptions can act on multiple targets of vascular dementia at the same time,to regulate the expression of multiple genes and improve cognitive dysfunction.

关 键 词：血管性痴呆 从心肾论治 心气不足 心肾不交 

分 类 号：R256.23[医药卫生—中医内科学]